Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?
Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?
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DOI：
10.3205/dgkh000290
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发表时间：
2017
影响因子：
3
通讯作者：
Trautmann M
中科院分区：
文献类型：
--
作者：
Exner M;Bhattacharya S;Christiansen B;Gebel J;Goroncy-Bermes P;Hartemann P;Heeg P;Ilschner C;Kramer A;Larson E;Merkens W;Mielke M;Oltmanns P;Ross B;Rotter M;Schmithausen RM;Sonntag HG;Trautmann M
在过去的几年中，由多重耐药革兰氏阴性菌引起的感染在世界各地急剧增加。这份共识文件是根据汉堡鲁道夫·舒尔克基金会邀请的一个国际专家小组的介绍、随后的讨论和对现有文献的评估编写的。它涉及革兰氏阴性菌的流行病学和固有特性，阐明抗生素耐药性传播的模式，强调宿主以及感染的传播途径和风险因素，死亡率，治疗和预防方案以及其在牲畜中流行的后果。遵循全球性的“同一健康”方法，并根据对这些病原体现有知识的评估，本文提出了预防和感染控制措施的建议，以及针对各种目标群体的建议，以应对革兰氏阴性菌构成的威胁，并防止新的抗生素耐药性的传播和出现。
In the past years infections caused by multidrug-resistant Gram-negative bacteria have dramatically increased in all parts of the world. This consensus paper is based on presentations, subsequent discussions and an appraisal of current literature by a panel of international experts invited by the Rudolf Schülke Stiftung, Hamburg. It deals with the epidemiology and the inherent properties of Gram-negative bacteria, elucidating the patterns of the spread of antibiotic resistance, highlighting reservoirs as well as transmission pathways and risk factors for infection, mortality, treatment and prevention options as well as the consequences of their prevalence in livestock. Following a global, One Health approach and based on the evaluation of the existing knowledge about these pathogens, this paper gives recommendations for prevention and infection control measures as well as proposals for various target groups to tackle the threats posed by Gram-negative bacteria and prevent the spread and emergence of new antibiotic resistances.