Tricyclic nonresponders: phenomenology and treatment.
Tricyclic nonresponders: phenomenology and treatment.
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三环无反应者：现象学和治疗。
DOI：
10.1176/ajp.143.3.345
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
S. Woodring
中科院分区：
文献类型：
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作者：
S. Roose;A. Glassman;B. Walsh;S. Woodring
为了确定三环类抗抑郁药无反应者的特征，作者回顾了接受过充分三环类药物治疗（通过血浆水平测定证实）的单相、非妄想性抑郁症住院患者的记录。将 17 名无反应患者与一组三环类药物反应者进行人口统计学和现象学变量的比较。尽管无反应者往往比反应者有更多的抑郁症发作史和更高的治疗前汉密尔顿量表焦虑评分，但无法通过临床或人口统计数据将他们与反应者区分开来。所有对三环类药物无反应的患者随后对单胺氧化酶抑制剂和/或 ECT 产生反应。
In an attempt to identify characteristics of tricyclic antidepressant nonresponders, the authors reviewed the records of inpatients with unipolar, nondelusional depression who had received adequate treatment (confirmed by plasma level determination) with tricyclics. The 17 patients who failed to respond were compared to a group of tricyclic responders with respect to demographic and phenomenologic variables. Although the nonresponders tended to have more previous episodes of depression and higher anxiety scores on the pretreatment Hamilton scale than the responders, they could not be distinguished from the responders by clinical or demographic data. All of the patients who failed to respond to tricyclics subsequently responded to monoamine oxidase inhibitors and/or ECT.
地昔帕明血浆浓度和抗抑郁反应。
影响因子：
--
作者：
Nelson,JC;Jatlow,P;Quinlan,DM;BowersJr,MB
通讯作者：
BowersJr,MB