Subclinical hypothyroidism: neurobehavioral features and beneficial effect of l-thyroxine treatment
Subclinical hypothyroidism: neurobehavioral features and beneficial effect of l-thyroxine treatment
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亚临床甲状腺功能减退症：神经行为特征和 L-甲状腺素治疗的有益效果
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
L. Baschieri
中科院分区：
文献类型：
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作者：
F. Monzani;P. Guerra;N. Caraccio;C. Pruneti;E. Pucci;M. Luisi;L. Baschieri
甲状腺功能减退症是已知的诱发神经和精神功能障碍。本研究的目的是评估选定的神经心理和行为特征的标准化测试的手段在一组14例亚临床甲状腺功能减退症患者的神经心理投诉和评估可能的影响，l-甲状腺素治疗对他们的表现。患者被提交到皇冠和脆经验指数和韦氏记忆量表，他们的神经行为测试和甲状腺激素的评分进行了比较，对照组的50名年龄和性别匹配的受试者。还进行了比较治疗前的评级和6个月的L-甲状腺素课程（0.1-0.15毫克/天）后获得的。韦氏记忆量表评分显示患者的记忆相关能力明显受损[记忆商（MQ）=89.1 ± 2.9; P=0.002（患者与对照组）]; Crown和Crisp经验指数评分显示未治疗患者和对照组在癔症方面存在中度差异，（P=0.03）、焦虑（P=0.05）、躯体主诉（P=0.0005）和抑郁特征（P=0.002）量表;总分也显著较高（42.0±3.8; P=0.005）。经甲状腺素治疗后，患者的记忆能力有明显改善，韦氏记忆量表（MQ = 99.9±4.0; P=0.002（治疗与未治疗）];躯体主诉（P=0.02）强迫症（P = 0.04）评级和牙冠和脆度体验指数总分（P=0.04）显着下降，就未经治疗的患者。本研究中观察到的甲状腺素治疗的显著效果表明，亚临床甲状腺功能减退症患者可能需要早期治疗，以提供针对其神经心理学改变的特异性治疗，并避免进展为坦率的甲状腺功能减退症。
SummaryFrank hypothyroidism is known to induce neurological and mental dysfunction. The aim of this study was to assess selected neuropsychological and behavioral features by means of standardized tests in a group of 14 patients with subclinical hypothyroidism who were free from neuropsychological complaints and to evaluate the possible effects of l-thyroxine treatment on their performance. Patients were submitted to the Crown and Crisp Experiential Index and to the Wechsler Memory Scale; their ratings on the neurobehavioral tests and their thyroid hormone profile were compared to those of a control group of 50 age- and sex-matched subjects. Comparison was also carried out between pretreatment ratings and those obtained following a 6-month l-thyroxine course (0.1–0.15 mg/day). The Wechsler Memory Scale ratings showed a significant impairment in patients' memory-related abilities [memory quotient (MQ)=89.1 ± 2.9; P=0.002 (patients versus controls)]; the Crown and Crisp Experiential Index ratings demonstrated moderate differences between untreated patients and controls with respect to hysteria (P=0.03), anxiety (P=0.05), somatic complaints (P=0.0005), and depressive features (P=0.002) scales; the total score was also significantly higher (42.0±3.8; P=0.005). After l-thyroxine treatment the patients' performances showed an improvement in memory skills, as evaluated by the Wechsler Memory Scale [MQ = 99.9±4.0; P=0.002 (treated versus untreated)]; somatic complaints (P=0.02) and obsessionality (P = 0.04) ratings and the Crown and Crisp Experiential Index total score (P=0.04) significantly decreased with respect to untreated patients. The remarkable effects of l-thyroxine treatment observed in the present study indicate that patients with subclinical hypothyroidism may require early therapy to provide specific treatment for their neuropsychological alterations and to avoid progression toward frank hypothyroidism.
影响因子：
4.8
作者：
CRANTZ, FR;SILVA, JE;LARSEN, PR
通讯作者：
LARSEN, PR
影响因子：
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作者：
Bauer,MS;Whybrow,PC;Winokur,A
通讯作者：
Winokur,A