Human amygdala activity during the expression of fear responses
Human amygdala activity during the expression of fear responses
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DOI：
10.1037/0735-7044.120.5.1187
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发表时间：
2006-12-01
影响因子：
1.9
通讯作者：
Helmstetter, Fred J.
中科院分区：
文献类型：
--
作者：
Cheng, Dominic T.;Knight, David C.;Helmstetter, Fred J.
恐惧的初始学习和随后的行为表达通常被视为具有潜在独特神经基质的独立过程。巴甫洛夫恐惧条件反射的实验动物研究表明，杏仁核对形成刺激关联和随后表达习得行为反应都很重要。在本研究中，利用事件相关功能磁共振成像和并发记录皮肤电导反应（SCRs），在两个差异条件反射实验中研究了条件恐惧自主表达过程中人类杏仁核的活动。试验是根据个体参与者的scr进行分类的。只有在一个信号既预测了休克又引发了显著的条件SCR的试验中，杏仁核才会有显著的反应。仅条件刺激呈现或自主神经活动是不够的。这些结果表明，杏仁核的活动可能具体反映了习得性恐惧反应的表达，并支持了该区域在情绪反应表达中起核心作用的观点。
The initial learning and subsequent behavioral expression of fear are often viewed as independent processes with potentially unique neural substrates. Laboratory animal studies of Pavlovian fear conditioning suggest that the amygdala is important for both forming stimulus associations and for subsequently expressing learned behavioral responses. In the present article, human amygdala activity was studied during the autonomic expression of conditional fear in two differential conditioning experiments with event-related functional magnetic resonance imaging and concurrent recording of skin conductance responses (SCRs). Trials were classified on the basis of individual participants' SCRs. Significant amygdala responding was detected only during trials on which a signal both predicted shock and elicited significant conditional SCR. Conditional stimulus presentation or autonomic activity alone was not sufficient. These results indicate that amygdala activity may specifically reflect the expression of learned fear responses and support the position that this region plays a central role in the expression of emotional reactions.