Mesial Temporal Sclerosis Associated With Methotrexate-Induced Leukoencephalopathy
Mesial Temporal Sclerosis Associated With Methotrexate-Induced Leukoencephalopathy
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DOI：
10.1016/j.pediatrneurol.2008.10.022
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发表时间：
2009-04-01
影响因子：
3.8
通讯作者：
Endo, Keigo
中科院分区：
文献类型：
--
作者：
Hamamoto, Kouhei;Oriuchi, Noboru;Endo, Keigo
内侧颞叶硬化症是儿童和青少年中一种常见的症状性、局部性癫痫，但它与急性淋巴细胞白血病一起发生的情况很少见。我们报告了一位13岁的急性淋巴细胞性白血病患者的临床记录和神经影像结果，他在被认为是由甲氨蝶呤引起的白质脑病后出现了反复的部分性癫痫发作。神经放射学影像显示海马区异常，与内侧颞叶硬化症的发现一致。急性淋巴细胞性白血病合并甲氨蝶呤诱发的白质脑病患者中，未见中枢性颞叶硬化症的报道。然而，我们的病例提示内侧颞叶硬化症的发病机制可能与甲氨蝶呤引起的神经毒性有关。(C)2009，Elsevier Inc.保留所有权利。
Mesial temporal sclerosis is a common form of symptomatic, localization-related epilepsy in children and adolescents, but its occurrence with acute lymphoblastic leukemia is rare. We present clinical records and neuroimaging results of a 13-year-old patient with acute lymphoblastic leukemia who developed recurrent partial seizures after an episode of leukoencephalopathy thought to be caused by methotrexate. Neuroradiologic images revealed hippocampal abnormalities consistent with the findings of mesial temporal sclerosis. Mesial temporal sclerosis was not previously reported in acute lymphoblastic leukemia patients with methotrexate-induced leukoencephalopathy. However, our case suggests that the pathogenesis of mesial temporal sclerosis may be associated with methotrexate-induced neurotoxicity. (C) 2009 by Elsevier Inc. All rights reserved.