Assignment of 1H, 13C, and 15N resonances for SF2 RNA recognition motif 2.
Assignment of 1H, 13C, and 15N resonances for SF2 RNA recognition motif 2.
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SF2 RNA 识别基序 2 的 1H、13C 和 15N 共振分配。
DOI：
10.1007/s10858-006-9134-6
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发表时间：
2007
影响因子：
2.7
通讯作者：
Tintaru AM
中科院分区：
文献类型：
--
作者：
Tintaru AM
SF2/ASF是一种典型的富含丝氨酸和精氨酸(SR)的剪接因子，参与结构性和选择性剪接、mRNA输出、稳定性和翻译(Sanford等人)。2005)。它由两个RNA识别基序(RRM)组成，连接到一个富含精氨酸和丝氨酸的C-末端结构域。RRM1包含预期的RNP-1和RNP-2基序，这些基序通常在该蛋白质折叠中找到。相反，RRM2在RNP-1和RNP-2基序中缺乏关键的芳香残基，这通常有助于与RNA的相互作用。然而，RRM2与RNA结合，并通过全长蛋白质帮助RNA识别和剪接位点选择。
SF2/ASF is a canonical serine and arginine (SR) rich splicing factor which is involved in constitutive and alternative splicing, mRNA export, stability and translation (Sanford et al. 2005). It consists of two RNA recognition motifs (RRM) linked to a C-terminal domain rich in arginine and serine. RRM1 contains the expected RNP-1 and RNP-2 motifs commonly found in this protein fold. In contrast, RRM2 lacks key aromatic residues within the RNP-1 and RNP-2 motifs which normally facilitate interaction with RNA. However, RRM2 binds RNA and contributes to RNA recognition and splice site selection by the full length protein.