SHORT-TERM METABOLIC EFFECTS OF RECOMBINANT HUMAN INSULIN-LIKE GROWTH FACTOR-I IN HEALTHY-ADULTS
SHORT-TERM METABOLIC EFFECTS OF RECOMBINANT HUMAN INSULIN-LIKE GROWTH FACTOR-I IN HEALTHY-ADULTS
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DOI：
10.1056/nejm198707163170303
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发表时间：
1987-07-16
影响因子：
158.5
通讯作者：
FROESCH, ER
中科院分区：
文献类型：
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作者：
GULER, HP;ZAPF, J;FROESCH, ER
胰岛素样生长因子I(IGF I)在结构上与胰岛素相似，并具有许多生物学特性。我们比较了8名健康志愿者(4名平均体重和4名女性)服用重组IGF-1(每公斤体重100微克[13.3 nmol])和胰岛素(每公斤0.15 IU[1 nmol])的短期代谢效果。对这两种激素的降糖反应在使用剂量上几乎相同。血糖在30分钟后达到最低水平。胰岛素样生长因子I组为1.78±0.29，胰岛素组为1.98±0.44 mmol/L。在摩尔基础上，IGF I在产生低血糖方面的效力仅为胰岛素的6%。胰岛素也比IGF I更有效地抑制脂肪分解。肾上腺素、去甲肾上腺素、生长激素、胰高血糖素和皮质醇对这两种药物的反应相似。胰岛素样生长因子I产生的低血糖可能是由于其快速静脉注射导致游离肽的超生理浓度所致。注射后15分钟，血清IGF-I水平由144.+-升高。基准线为每毫升38 ng至424+-。56，其中80%在血浆中是游离的(不与IGF载体蛋白结合)。确定IGF I的任何短期代谢效应是否有任何临床应用将需要进一步的研究。
Insulin-like growth factor I (IGF I) is structurally similar to insulin and shares many of its biologic properties. We compared the short-term metabolic effects of recombinant IGF 1 (100 .mu.g [13.3 nmol) per kilogram of body weight) and insulin (0.15 IU [1 nmol] per kilogram) in eight healthy volunteers (four mean and four women). The hypoglycemic responses to both hormones were nearly identical in the doses used. The lowest blood glucose levels were reached after 30 minutes. 1.98.+-.0.44 mmol per liter after IGF I had 1.78.+-.0.29 after insulin. On a molar basis, IGF I was only 6 percentage as potent as insulin in the production of hypoglycemia. Insulin also inhibited lipolysis more effectively than IGF I. Levels of epinephrine, norepinephrine, growth hormone, glucagon, and cortisol responded similarly to both agents. The hypoglycemia produced by IGF I is probably due to the supraphysiologic concentrations of the free peptide that result from its rapid intravenous injection. Fifteen minutes after injection, the serum level of IgF I increased from 144 .+-. 38 ng per milliliter at base line to 424 .+-. 56, of which 80 percent was free in the plasma (not bound to IGF carrier proteins). The determination of whether any of the short-term metabolic effects of IGF I have any clinical application will require further investigation.