Molecular biology and pathology of lymphangiogenesis.
Molecular biology and pathology of lymphangiogenesis.
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DOI：
10.1146/annurev.pathmechdis.3.121806.151515
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发表时间：
2008-01
期刊：
影响因子：
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通讯作者：
Terhi Karpanen;K. Alitalo
中科院分区：
文献类型：
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作者：
Terhi Karpanen;K. Alitalo
淋巴管系统对于维持组织液平衡、免疫监视和吸收肠道中的脂肪酸至关重要。淋巴管也在诸如肿瘤转移、水肿和各种炎性病症等疾病的发病机制中至关重要。在过去的几年里，控制或治疗这些疾病的尝试引起了人们对淋巴管研究的极大兴趣。近年来，淋巴管内皮细胞特异性标志物和淋巴管研究模型的发现，使淋巴管生物学研究取得了重大技术进展，并发现了许多重要的淋巴管生长调节因子。尽管取得了这些重大成就，我们对淋巴管发育和发病机制的理解仍然相当有限。几个关键问题仍有待解决，包括靶向淋巴管系统的不同途径的相对贡献，淋巴成熟的分子和细胞过程，以及肿瘤通过淋巴系统转移的详细机制。
The lymphatic vasculature is essential for the maintenance of tissue fluid balance, immune surveillance, and adsorption fatty acids in the gut. The lymphatic vessels are also crucially involved in the pathogenesis of diseases such as tumor metastasis, lymphedema, and various inflammatory conditions. Attempts to control or treat these diseases have drawn a lot of interest to lymphatic vascular research during the past few years. Recently, several markers specific for lymphatic endothelium and models for lymphatic vascular research have been characterized, enabling great technical progress in lymphatic vascular biology, and many critical regulators of lymphatic vessel growth have been identified. Despite these significant achievements, our understanding of the lymphatic vessel development and pathogenesis is still rather limited. Several key questions remain to be resolved, including the relative contributions of different pathways targeting lymphatic vasculature, the molecular and cellular processes of lymphatic maturation, and the detailed mechanisms of tumor metastasis via the lymphatic system.