Store-operated Ca2+ channels in airway epithelial cell function and implications for asthma.
Store-operated Ca2+ channels in airway epithelial cell function and implications for asthma.
复制标题
DOI：
10.1098/rstb.2015.0424
复制
发表时间：
2016-08-05
期刊：
影响因子：
--
通讯作者：
Parekh AB
中科院分区：
文献类型：
--
作者：
Samanta K;Parekh AB
肺的上皮细胞位于宿主及其环境的界面处，因此直接暴露于吸入的空气传播的颗粒。气道上皮细胞不是作为一个简单的物理屏障，而是检测过敏原和其他刺激物，然后通过释放过多的分泌信号来帮助组织随后的免疫反应。这些信号中的许多是响应于质膜中的钙库操纵的Ca2+通道的开放而产生的。在这篇综述中，我们描述了气道储存操纵通道的特性及其在调节气道上皮细胞功能中的作用。这篇文章是主题问题的一部分“进化将Ca2+和ATP结合在一起来控制生命和死亡”。
The epithelial cells of the lung are at the interface of a host and its environment and are therefore directly exposed to the inhaled air-borne particles. Rather than serving as a simple physical barrier, airway epithelia detect allergens and other irritants and then help organize the subsequent immune response through release of a plethora of secreted signals. Many of these signals are generated in response to opening of store-operated Ca2+ channels in the plasma membrane. In this review, we describe the properties of airway store-operated channels and their role in regulating airway epithelial cell function. This article is part of the themed issue ‘Evolution brings Ca2+ and ATP together to control life and death’.