Recent developments in lipid-based pharmaceutical nanocarriers
Recent developments in lipid-based pharmaceutical nanocarriers
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DOI：
10.2741/3795
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Torchilin, Vladimir P.
中科院分区：
文献类型：
--
作者：
Musacchio, Tiziana;Torchilin, Vladimir P.
在纳米颗粒载体的广泛范围内，聚合物和脂核胶束、脂质体、固体纳米颗粒和许多其他载体已经表现出极大的生物学特性，这使得它们成为优异的药物递送系统。特别地，胶束和脂质体已被证明在血液中具有良好的寿命，这允许它们在具有受损脉管系统的病理区域中积累;当各种靶向配体连接到纳米载体的表面或表面连接的细胞穿透分子时，可以具有对疾病部位的特异性靶向具有刺激敏感性，允许药物在某些病理条件下从载体释放;并显示出与载体负载的各种造影材料的对比特性，其允许在体内直接观察载体。基于同一系统中几种有用性质的组合的“多功能药物纳米载体”的工程化可以显著增强许多治疗和诊断方案的功效。本文综述了纳米医学领域的现状和未来发展方向，特别关注两种基于脂质的纳米颗粒系统：脂质体和胶束。
Within the broad spectrum of nanoparticulate carriers, polymeric and lipid-core micelles, liposomes, solid nanoparticles and many others have demonstrated great biological properties which make them excellent pharmaceutical delivery systems. In particular, micelles and liposomes have been shown to have good longevity in the blood that allows their accumulation in pathological areas with a compromised vasculature; can possess specific targeting to disease sites when various targeting ligands are attached to the surface of the nanocarriers or to surface-attached cell-penetrating molecules (like TAT peptide) to enhance intracellular penetration; possess stimulus-sensitivity allowing for drug release from the carriers under certain pathological conditions; and show contrast properties with carrier loading of various contrast materials that allow for direct carrier visualization in vivo. The engineering of "multifunctional pharmaceutical nanocarriers" based on the combination of several useful properties in the same system can significantly enhance the efficacy of many therapeutic and diagnostic protocols. This review considers the current status and next future directions in the emerging area of nanomedicine with particular attention to two lipid-based nanoparticulate systems: liposomes and micelles.