Diagnosis and treatment of sudden-onset sensorineural hearing loss: A study of 51 patients
Diagnosis and treatment of sudden-onset sensorineural hearing loss: A study of 51 patients
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DOI：
10.1067/mhn.2003.50
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发表时间：
2003-01-01
影响因子：
3.4
通讯作者：
Spitzer, JB
中科院分区：
文献类型：
--
作者：
Zadeh, MH;Storper, IS;Spitzer, JB
目的：本研究的目的是确定类固醇和抗病毒治疗的疗效在特发性突发性感音神经性听力损失（SSNHL）的管理。研究设计和设置：我们进行了一项回顾性研究的患者提出的学术三级保健中心。对51例患者进行了评价。结果：37例患者（73%）听力恢复。治疗后91%的眩晕患者及所有的中频听力损失和上斜听力损失患者均恢复正常（P < 0.05）。恢复与年龄、听力损失发作和听力图类型显著相关;然而，结果与性别、眩晕、耳鸣或偏侧性无关（P < 0.05）。结论：我们的治疗方案产生了恢复率，超过了自发恢复率。与先前的研究不同，所有上斜和中频SSNHL患者均已恢复。此外，眩晕并不意味着预后不良。意义：抗病毒治疗和增加类固醇治疗的时间长度可能在提高恢复率方面发挥作用。
OBJECTIVE: The study purpose was to determine the efficacy of steroid and antiviral therapy in the management of idiopathic sudden sensorineural hearing loss (SSNHL).STUDY DESIGN AND SETTING: We conducted a retrospective study of patients presenting to an academic tertiary care center. Fifty-one patients were evaluated. All patients were placed on the same treatment protocol.RESULTS: Thirty-seven patients (73%) had recovery of hearing. Ninety-one percent of patients with vertigo and all patients with mid-frequency hearing loss and up-sloping hearing loss recovered with treatment (P < 0.05). Recovery was significantly related to age, onset of hearing loss, and audiogram type; however outcome was not significantly related to gender, vertigo, tinnitus, or laterality (P < 0.05).CONCLUSION: Our treatment protocol produced a recovery rate, which exceeds the spontaneous recovery rate. Unlike prior studies, all patients with up-sloping and mid-frequency SSNHL had recovery. In addition, vertigo did not indicate a poor prognosis.SIGNIFICANCE: Antiviral therapy and increased length of steroid treatment may play a role in the improved recovery rates.