Localization and patterns of Cerebral dyschromatopsia: A study of subjects with prospagnosia.
Localization and patterns of Cerebral dyschromatopsia: A study of subjects with prospagnosia.
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DOI：
10.1016/j.neuropsychologia.2016.06.012
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发表时间：
2016-08
期刊：
影响因子：
2.6
通讯作者：
Barton JJS
中科院分区：
文献类型：
--
作者：
Moroz D;Corrow SL;Corrow JC;Barton ARS;Duchaine B;Barton JJS
脑部色觉障碍有时与获得性面孔失认有关。鉴于导致获得性面容失认的结构损害的多样性，本研究旨在研究面容失认相关色觉障碍的结构相关性，并确定这种颜色处理缺陷是否也会伴随发育性面容失认。此外，我们还研究了脑部色觉障碍是否以一致的色调损害模式为典型。我们使用Farnsworth-Munsell 100色调测试，研究了12名获得性面容失认症患者和9名发育性面容失认症患者的色调辨别，以及42名匹配的对照组。我们发现6名后天性面容失认症患者、5名双侧患者和1名单侧枕颞部病变患者的色调辨别能力受损。结构MRI分析显示病变在左右舌回和梭形回有最大重叠。对他们的错误分数进行傅立叶分析，显示出类似三视的缺陷和蓝绿色的损害，类似于健康对照组表现出的倾向。三名受试者还显示了新的第四傅立叶分量，表明紫色和绿黄色区域有额外的峰缺陷。没有发育性面认失认症受试者的色调辨别能力受损。在我们的面孔失认症受试者中，后天性梭形回病变的患者会发生色觉障碍，通常是双侧的，但有时是单侧的。变色障碍主要表现为正常反视倾向的加重。这些缺陷有时会伴随着额外的缺陷，尽管这些缺陷可能是测试过程中的瑕疵。
Cerebral dyschromatopsia is sometimes associated with acquired prosopagnosia. Given the variability in structural lesions that cause acquired prosopagnosia, this study aimed to investigate the structural correlates of prosopagnosia-associated dyschromatopsia, and to determine if such color processing deficits could also accompany developmental prosopagnosia. In addition, we studied whether cerebral dyschromatopsia is typified by a consistent pattern of hue impairments. We investigated hue discrimination in a cohort of 12 subjects with acquired prosopagnosia and 9 with developmental prosopagnosia, along with 42 matched controls, using the Farnsworth-Munsell 100-hue test. We found impaired hue discrimination in six subjects with acquired prosopagnosia, five with bilateral and one with a unilateral occipitotemporal lesion. Structural MRI analysis showed maximum overlap of lesions in the right and left lingual and fusiform gyri. Fourier analysis of their error scores showed tritanopic-like deficits and blue-green impairments, similar to tendencies displayed by the healthy controls. Three subjects also showed a novel fourth Fourier component, indicating additional peak deficits in purple and green-yellow regions. No subject with developmental prosopagnosia had impaired hue discrimination. In our subjects with prosopagnosia, dyschromatopsia occurred in those with acquired lesions of the fusiform gyri, usually bilateral but sometimes unilateral. The dyschromatopsic deficit shows mainly an accentuation of normal tritatanopic-like tendencies. These are sometimes accompanied by additional deficits, although these could represent artifacts of the testing procedure.