Genomic insights of body plan transitions from bilateral to pentameral symmetry in Echinoderms
Genomic insights of body plan transitions from bilateral to pentameral symmetry in Echinoderms
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DOI：
10.1038/s42003-020-1091-1
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发表时间：
2020-07-10
影响因子：
5.9
通讯作者：
Irie, Naoki
中科院分区：
文献类型：
--
作者：
Li, Yongxin;Omori, Akihito;Irie, Naoki
棘皮动物是一种特殊的两侧对称动物，从两侧对称的幼虫发育成五室对称的成体。然而，这种独特的转变在进化和发展中的遗传基础仍有待澄清。在这里，我们报告新测序的基因组，发育转录组，和蛋白质组的不同棘皮动物，包括绿色海胆（L。variegatus）、海参（A.），并特别强调了最早分化的棘皮动物的姐妹群，羽状星星（A. japonica）。我们了解到棘皮动物的最后一个共同祖先保留了一个组织良好的Hox簇，让人想起半索动物，并具有参与内骨骼发育的基因组。此外，与其他动物群体不同，最保守的发育阶段不是在身体计划建立阶段，通常参与双边性的基因似乎在五聚体轴发育中发挥作用。这些结果增强了我们对近500 Mya的原口动物和后口动物分歧的理解。李等人利用基因组学、转录组学和蛋白质组学数据研究了棘皮动物成体五分体型的进化和遗传基础。他们确定棘皮动物最后的共同祖先包含有组织的Hox簇和内骨骼基因，并表明双侧发育基因的协同选择参与了五聚体计划的进化。
Echinoderms are an exceptional group of bilaterians that develop pentameral adult symmetry from a bilaterally symmetric larva. However, the genetic basis in evolution and development of this unique transformation remains to be clarified. Here we report newly sequenced genomes, developmental transcriptomes, and proteomes of diverse echinoderms including the green sea urchin (L. variegatus), a sea cucumber (A. japonicus), and with particular emphasis on a sister group of the earliest-diverged echinoderms, the feather star (A. japonica). We learned that the last common ancestor of echinoderms retained a well-organized Hox cluster reminiscent of the hemichordate, and had gene sets involved in endoskeleton development. Further, unlike in other animal groups, the most conserved developmental stages were not at the body plan establishing phase, and genes normally involved in bilaterality appear to function in pentameric axis development. These results enhance our understanding of the divergence of protostomes and deuterostomes almost 500 Mya. Li et al. investigate the evolution and genetic basis of the adult pentameral body plan in echinoderms using genomic, transcriptomic, and proteomic data. They determine that the last common ancestor of echinoderms contained an organized Hox cluster and endoskeleton genes, and suggest that cooption of bilateral development genes was involved in evolution of the pentameric body plan.