The temporal relationship between alcohol consumption and HIV-medication adherence: A multilevel model of direct and moderating effects
The temporal relationship between alcohol consumption and HIV-medication adherence: A multilevel model of direct and moderating effects
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DOI：
10.1037/a0012664
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发表时间：
2008-09-01
影响因子：
4.2
通讯作者：
Mustanski, Brian
中科院分区：
文献类型：
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作者：
Parsons, Jeffrey T.;Rosof, Elana;Mustanski, Brian
先前的研究记录了酒精使用与HIV药物依从性之间的关联，但无法区分代表酒精暂时相关影响的人与人之间的特征和人与人之间的特征。层次线性模型（HLM）探讨了过去14天内和人与人之间的依从性预测因子。以及在272名有酒精问题的艾滋病毒阳性男性和女性中调节饮酒事件水平影响的因素。在参与者喝酒的那一组，他们不坚持服药的几率几乎高出9倍。每喝一杯，患病几率增加20%。认知和酒精因素对依从性有显著的人际影响。对严格遵守药物治疗的重要性有强烈和严格信念的人受到每一剂量酒精的影响更大，而酗酒和有问题的人受到每一杯酒的影响较小。治疗方案的复杂性增加了1杯或更多酒的效果。这些结果强调了促进酒精使用成人药物依从性的重要性。特别是在治疗方案复杂或对HIV药物治疗有高度信心和积极态度的患者中。
Previous studies documenting an association between alcohol use and HIV medication nonadherence, have been unable to distinguish between-persons characteristics from within-person characteristics representing the temporally linked effects of alcohol. Hierarchical Linear Modeling (HLM) explored within- and between-person predictors of adherence during the past 14 days. as well as factors that moderate the event-level effects of alcohol consumption among 272 HIV-positive men and women with alcohol problems. On (lays in which participants drank, they had almost 9 times higher odds of medication nonadherence. with each drink increasing the odds by 20%. The cognitive and alcohol factors had significant between-person effects on adherence. Individuals with strong and rigid beliefs about the importance of strict medication adherence were significantly more affected by each dose of alcohol, while individuals with more alcohol use and problems were less affected by each drink. Regimen complexity increased the effects of having I or more drinks. These results highlight the importance of promoting medication adherence among alcohol-using adults. especially among patients with complex regimens or with high confidence and positive attitudes toward HIV medication.