A Multiscale Model of the Electrophysiological Basis of the Human Electrogastrogram
A Multiscale Model of the Electrophysiological Basis of the Human Electrogastrogram
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DOI：
10.1016/j.bpj.2010.08.067
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发表时间：
2010-11-03
影响因子：
3.4
通讯作者：
Pullan, Andrew J.
中科院分区：
文献类型：
--
作者：
Du, Peng;O'Grady, Gregory;Pullan, Andrew J.
胃的运动是由一种被称为“慢波”的电活动协调的，而慢波心律失常会导致运动障碍。临床评估胃节律障碍的一个主要方法是胃电图（EGG）；然而，由于其电生理基础的不确定性，EGG的临床应用受到限制。在这项研究中，通过基于生物物理的细胞电事件连续描述，结合受试者特异性的人类胃模型和高分辨率电映射数据，生成了胃慢波的多尺度模型。然后，在解剖躯干模型中使用正演建模方法应用该模型，以确定慢波活动如何累积以产生EGG电位。模拟的脑电图电位在振幅（0.27 ~ 0.33 mV）和持续时间（9.2 ~ 15.3 s）上存在空间差异，这种差异的来源与底层慢波活动的激活时间有关。该模型构成了EGG电生理基础的改进理论，并为优化EGG电极的放置和解释疾病状态下发生的EGG变化提供了框架。
The motility of the stomach is coordinated by an electrical activity termed "slow waves", and slow-wave dysrhythmias contribute to motility disorders. One major method for clinically evaluating gastric dysrhythmias has been electrogastrography (EGG); however, the clinical utility of EGG is limited partly due to the uncertainty regarding its electrophysiological basis. In this study, a multiscale model of gastric slow waves was generated from a biophysically based continuum description of cellular electrical events, coupled with a subject-specific human stomach model and high-resolution electrical mapping data. The model was then applied using a forward-modeling approach, within an anatomical torso model, to define how slow wave activity summates to generate the EGG potentials. The simulated EGG potentials were shown to be spatially varying in amplitude (0.27-0.33 mV) and duration (9.2-15.3 s), and the sources of this variance were quantified with respect to the activation timings of the underlying slow wave activity. This model constitutes an improved theory of the electrophysiological basis of the EGG, and offers a framework for optimizing the placement of EGG electrodes, and for interpreting the EGG changes occurring in disease states.