Constraining Whole-Genome Duplication Events in Geological Time.
Constraining Whole-Genome Duplication Events in Geological Time.
复制标题
限制地质时期的全基因组复制事件。
DOI：
10.1007/978-1-0716-2561-3_7
复制
发表时间：
2023
期刊：
影响因子：
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通讯作者：
Clark JW
中科院分区：
文献类型：
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作者：
Clark JW
全基因组复制（WGD）事件发生的时间对于理解其在进化中的作用至关重要，并支持许多将WGD与多样性和复杂性增加联系起来的假设。因此，相对于它们的宏观进化结果，估计WGD事件发生时间的方法是相当重要的。分子钟方法有助于直接估计WGD事件的绝对时间，整合物种之间序列进化速度的信息，同时适应化石记录固有的不确定性。本文介绍了在MCMCtree程序中通过分子钟方法构建化石校准和估计WGD事件年龄的最佳实践，并给出了一个基于开花山茱萸（Cornus）中具有良好特征的WGD事件的示例数据集。本文提出的方法允许估计WGD事件和随后的物种形成事件的年龄，允许探索WGD与宏观进化结果之间的关系。在我们的例子中，我们表明，在开花山茱萸的情况下，WGD事件早于白垩纪末的大灭绝，这两个事件可能是独立的。
The timing of whole-genome duplication (WGD) events is crucial to understanding their role in evolution and underpins many hypotheses linking WGD to increased diversity and complexity. As such, means of estimating the timing of the WGD events relative to their macroevolutionary outcomes are of considerable importance. Molecular clock methods facilitate direct estimation of the absolute timing of WGD events, integrating information on the rate of sequence evolution between species while accommodating the uncertainty inherent to the fossil record. We present an explanation of the best practice for constructing fossil calibrations and estimating the age of WGD events via molecular clock methods in the program MCMCtree, with an example dataset based on a well-characterized WGD event within the flowering dogwoods (Cornus). The approach presented herein allows for the estimation of the age of WGD events and subsequent speciation events, allowing the relationship between WGD and the macroevolutionary outcomes to be explored. In our example, we show that in the case of flowering dogwoods, the WGD event long predates the end-Cretaceous mass extinction and that the two events may be independent.