Hyper-inflammatory Syndrome in a Child With COVID-19 Treated Successfully With Intravenous Immunoglobulin and Tocilizumab.
Hyper-inflammatory Syndrome in a Child With COVID-19 Treated Successfully With Intravenous Immunoglobulin and Tocilizumab.
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DOI：
10.1007/s13312-020-1901-z
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发表时间：
2020-07-15
影响因子：
2.3
通讯作者：
Ramanan, A V
中科院分区：
文献类型：
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作者：
Balasubramanian, S;Nagendran, T M;Ramanan, A V
然而，有报告称，在过去几周内，欧洲和美国的儿童因新的多系统炎症综合征而出现明显不适[1]。我们报告了一名患有COVID-19的儿童，他具有中毒性休克综合征（TSS）和川崎病（KD）的重叠特征。一名先前健康的8岁男孩出现发烧，咳嗽和喉咙痛。由于高烧，他在发病第4天住进了当地医院。检查显示嗜中性白细胞增多症（总白色血细胞计数23，000/µL，中性粒细胞89%）伴急性期反应物升高（C反应蛋白，CRP 120 mg/L）。胸部X线显示右上叶和中叶浸润。严重急性呼吸道疾病新型冠状病毒2型（SARS-CoV-2）逆转录聚合酶链反应（RT-PCR）为阴性。治疗经验开始与头孢曲松和阿奇霉素。尽管接受了三天的治疗，但他仍然高烧不退，呼吸道症状恶化，并被转诊到我们医院。
However, there are reports of children presenting significantly unwell across Europe and USA in the last couple of weeks with a new multisystem inflammatory syndrome [1]. We report a child with COVID-19 who had overlapping features of Toxic Shock Syndrome (TSS) and Kawasaki disease (KD).A previously well, eight-year-old boy presented with fever, cough and throat pain. He was admitted to a local hospital on day 4 of illness in view of high-grade fever spikes. Investigations showed neutrophilic leukocytosis (total white blood cell count 23,000/µL, Neutrophils 89%) with raised acute phase reactants (C-reactive protein, CRP 120 mg/L). Chest X-ray showed right upper and middle lobe infiltrates. Reverse transcriptase polymerase chain reaction (RT-PCR) for severe acute respiratory illness novel coronavirus 2 (SARS-CoV-2) was negative. Treatment was empirically started with ceftriaxone and azithromycin. Despite treatment for three days, he continued to have high fever, worsening respiratory symptoms and was referred to our hospital.