Myocardial extraction and retention of 2-iododesmethylimipramine: a novel flow marker.
Myocardial extraction and retention of 2-iododesmethylimipramine: a novel flow marker.
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2-碘去甲基丙咪嗪的心肌提取和保留：一种新型流量标记物。
DOI：
10.1152/ajpheart.1986.250.6.h1060
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Bassingthwaighte,JB
中科院分区：
文献类型：
--
作者：
Little,SE;Link,JM;Krohn,KA;Bassingthwaighte,JB
用于测量区域流量的理想沉积标记物在通过毛细管通道过程中被完全提取并永久保留。β标记去甲基米帕明([~3H]DMI)是一种近乎理想的血流标志物。为了获得伽马和正电子发射标记，将DMI进行碘化，形成2-碘代甲基丙咪胺(IDMI)。IDMI比DMI更亲油。在生理盐水灌流的离体兔心脏中，其跨器官萃取率大于99%，在平均流量高达3.5ml×g~(-1)×min~(-1)的情况下，5min的保留率大于98%。在洗涤过程中，逃逸分数小于0.1%X·min~(-1)，且与流量无关。在离体血液灌流的兔心中，萃取率仍为98%，但在1.6mlXg-1Xmin-1的流量下，5min后保留率低至86%。逃逸分数可达2%×min-1，但与流量无关。尽管这种相对快速的流失，但在许多分钟内，区域性IDMI沉积仍与区域性血流成正比。因此，IDMI可作为一种体外可检测的“分子微球”用于活体心肌血流显像。
An ideal deposition marker for measuring regional flow is completely extracted during transcapillary passage and permanently retained. beta-Labeled desmethylimipramine ([3H]DMI) is a nearly ideal flow marker. To obtain gamma- and positron-emitting markers, DMI was iodinated to form 2-iododesmethylimipramine (IDMI). IDMI was more lipophilic than DMI. In isolated saline-perfused rabbit hearts its transorgan extraction was greater than 99%; and retention was greater than 98% at 5 min at mean flows of up to 3.5 ml X g-1 X min-1. During washout, the fractional escape rate was less than 0.1% X min-1 and was independent of flow. In isolated blood-perfused rabbit hearts, extraction was still 98%, but retention was as low as 86% after 5 min at a flow of 1.6 ml X g-1 X min-1. The fractional escape rate was up to 2% X min-1 but independent of flow. Despite this relatively rapid loss, regional IDMI deposition remains proportional to regional flow for many minutes. Therefore IDMI is useful as an externally detectable "molecular microsphere" for myocardial flow imaging in vivo.
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