Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome
Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome
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DOI：
10.1093/annonc/mdh136
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发表时间：
2004-04-01
影响因子：
50.5
通讯作者：
Soria, JC
中科院分区：
文献类型：
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作者：
Spano, JP;Andre, F;Soria, JC
背景：CXCR 4的表达与乳腺癌和黑色素瘤不同模型的转移性播散有关。在本研究中，我们评估了CXCR 4在非小细胞肺癌（NSCLC）中的表达以及CXCR 4表达与I期疾病预后之间的关系。患者和方法：使用免疫组化分析，我们回顾性分析了61例完全切除的病理证实的I期NSCLC患者的标本中CXCR 4的表达，这些患者的临床随访数据可用。在本研究中，我们发现：CXCR 4在I期NSCLC的肿瘤细胞中表达; CXCR 4位于肿瘤细胞的细胞核和/或细胞质中;在17例病例中观察到强核染色（29.8%）;肿瘤中CXCR 4-核染色阳性的患者的生存期明显长于肿瘤无核表达的患者（P = 0.039，对数秩检验）。结论：CXCR 4强阳性表达与早期NSCLC的预后密切相关。这一重要的临床和生物学发现的机制需要进一步探索。
Background: The expression of CXCR4 has been implicated in metastatic dissemination in different models of breast cancer and melanoma. In the present study, we evaluated CXCR4 expression in non-small-cell lung cancer (NSCLC) and the relationship between CXCR4 expression and the prognosis of stage I disease.Patients and methods: Using immunohistochemical analysis, we retrospectively analyzed CXCR4 expression in specimens from 61 patients with completely resected pathologically confirmed stage I NSCLC for whom clinical follow-up data were available.Results: In the present study, we have shown that: CXCR4 is expressed by tumor cells in stage I NSCLC; CXCR4 is located in the nucleus and/or in the cytoplasm of tumor cells; strong nuclear staining was observed in 17 cases (29.8%); patients whose tumors had CXCR4-positive nuclear staining had a significantly longer duration of survival than patients whose tumors had no nuclear expression (P = 0.039, log-rank test). Interestingly, the 5-year metastasis rates were 23.5% and 34.1% in patients with CXCR4-positive and CXCR4-negative nuclear expression, respectively (P = 0.2).Conclusion: Strong CXCR4-positive nuclear staining was associated with a significantly better outcome in early-stage NSCLC. The mechanisms underlying this clinically and biologically important finding need to be further explored.