Functional analysis of atypical mutations in exons 13 and 15 of JAK2 gene in myeloproliferative neoplasms
Functional analysis of atypical mutations in exons 13 and 15 of JAK2 gene in myeloproliferative neoplasms
复制标题
DOI：
10.1111/ijlh.13398
复制
发表时间：
2020-11
影响因子：
3
通讯作者：
M. Luo;Tingting Tian;Yaofang Zhang;Xialin Zhang;Juan Xie;Jing Xu;Weixiao Ren;Chuchu Tian;Jiaxuan Wang;Yanhong Tan;Hongwei Wang;Xiuhua Chen
中科院分区：
文献类型：
--
作者：
M. Luo;Tingting Tian;Yaofang Zhang;Xialin Zhang;Juan Xie;Jing Xu;Weixiao Ren;Chuchu Tian;Jiaxuan Wang;Yanhong Tan;Hongwei Wang;Xiuhua Chen
The article focuses on classic Philadelphia chromosome negative myeloproliferative neoplasms are a group of clonal stem cell diseases characterized by excessive proliferation of one or more differentiated myeloid lineages, including polycythaemia vera, essential thrombocytosis and primary myelofibrosis. Topics include the JH2 domain to lose its inhibitory effect on the C-terminal tyrosine kinase domain, and the studies on exons 13 and 15 near the mutation hotspots of JAK2 are limited.
