Smooth muscle cell contraction increases the critical buckling pressure of arteries
Smooth muscle cell contraction increases the critical buckling pressure of arteries
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DOI：
10.1016/j.jbiomech.2012.11.040
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发表时间：
2013-02-22
影响因子：
2.4
通讯作者：
Han, Hai-Chao
中科院分区：
文献类型：
--
作者：
Hayman, Danika M.;Zhang, Jinzhou;Han, Hai-Chao
最近的体外实验表明，在内压增加或轴向拉伸减少的情况下，动脉可能会弯曲成在体内老化或患病的动脉中常见的曲折模式。提示屈曲是动脉弯曲形成的一种可能机制。血管张力对动脉力学特性有显著影响，但其对动脉屈曲的影响尚不清楚。本研究的目的是确定平滑肌细胞收缩对动脉临界屈曲压力的影响。猪颈总动脉在体外器官培养系统中生理流量和压力下灌流过夜。调整灌流压力，以确定这些动脉在活体时的临界屈曲压力，以及基础状态和去甲肾上腺素和硝普钠刺激的平滑肌收缩和松弛后的轴向拉伸比减小(1.5和1.3)。结果表明，收缩时的临界屈曲压力显著高于松弛时的临界屈曲压力(分别为97.3 mm Hgvs72.9 mm Hg和93.7 mm Hgvs58.6 mm Hg1.5，p<0.05)。这些结果表明，动脉平滑肌细胞的收缩增加了动脉的稳定性。(C)2012爱思唯尔有限公司。保留所有权利。
Recent in vitro experiments demonstrated that arteries under increased internal pressure or decreased axial stretch may buckle into the tortuous pattern that is commonly observed in aging or diseased arteries in vivo. It suggests that buckling is a possible mechanism for the development of artery tortuosity. Vascular tone has significant effects on arterial mechanical properties but its effect on artery buckling is unknown. The objective of this study was to determine the effects of smooth muscle cell contraction on the critical buckling pressure of arteries. Porcine common carotid arteries were perfused in an ex vivo organ culture system overnight under physiological flow and pressure. The perfusion pressure was adjusted to determine the critical buckling pressure of these arteries at in vivo and reduced axial stretch ratios (1.5 and 1.3) at baseline and after smooth muscle contraction and relaxation stimulated by norepinephrine and sodium nitroprusside, respectively. Our results demonstrated that the critical buckling pressure was significantly higher when the smooth muscle was contracted compared with relaxed condition (97.3 mmHg vs 72.9 mmHg at axial stretch ratio of 1.3 and 93.7 mmHg vs 58.6 mmHg at 1.5, p < 0.05). These results indicate that arterial smooth muscle cell contraction increased artery stability. (c) 2012 Elsevier Ltd. All rights reserved.