The prognostic significance of Jun transcription factors in ovarian cancer
The prognostic significance of Jun transcription factors in ovarian cancer
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DOI：
10.1007/s00432-013-1489-y
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发表时间：
2013-10-01
影响因子：
3.6
通讯作者：
Milde-Langosch, Karin
中科院分区：
文献类型：
--
作者：
Eckhoff, Kerstin;Flurschuetz, Roland;Milde-Langosch, Karin
Jun蛋白（c-Jun、JunD和JunB）在细胞增殖、凋亡和血管生成的调节中起重要作用。已经确定，这些蛋白质参与几种肿瘤类型的癌变和进展。然而，很少有人知道Jun蛋白在浸润性上皮性卵巢癌患者的预后意义，我们分析了新鲜冷冻组织的161例卵巢癌患者通过使用Western blot分析，调查蛋白水平的JunB，JunD，c-Jun和磷酸化c-Jun（pc-Jun Ser 63）。结果与临床病理预后参数和生存数据相关，pc-Jun高表达与较短的无进展生存期（14 vs. 16个月，p = 0.017）和总生存期（25 vs. 41个月，p = 0.038）显著相关。在JunD的情况下，中等蛋白水平与更好的预后相关，与弱或强JunD表达相比，导致更长的无进展生存期和总生存期（弱/中等/强JunD表达病例的PFS：14 vs. 19.5 vs. 16个月，p = 0.011; OAS：32 vs. 42 vs. 35.5个月，p = 0.009）。多变量考克斯回归分析证实了一个独立的和显着的影响，pc-Jun和JunD对患者的pregnancy.Our结果表明，Jun蛋白（pc-Jun和JunD）影响癌的发生和肿瘤的进展，这表明在人类卵巢癌的预后预测的重要作用。
The Jun proteins (c-Jun, JunD and JunB) play an important role in the regulation of cell proliferation, apoptosis and angiogenesis. It is well established that these proteins participate in the carcinogenesis and progression in several tumour types. However, little is known about the prognostic significance of Jun proteins in patients with invasive epithelial ovarian carcinoma.We analysed fresh-frozen tissues of 161 ovarian cancer patients by using Western blot analysis to investigate protein levels of JunB, JunD, c-Jun and phosphorylated c-Jun (pc-Jun Ser63). The results were correlated with clinicopathologic prognostic parameters and survival data.A high pc-Jun expression was significantly associated with shorter progression-free survival (14 vs. 16 months, p = 0.017) and overall survival (25 vs. 41 months, p = 0.038). In case of JunD, moderate protein levels were associated with a better prognosis, leading to longer progression-free and overall survival compared to weak or strong JunD expression (PFS in cases with weak/moderate/strong JunD expression: 14 vs. 19.5 vs. 16 months, p = 0.011; OAS: 32 vs. 42 vs. 35.5 months, p = 0.009). Multivariate Cox regression analysis confirmed an independent and significant impact of pc-Jun and JunD on the patient's prognosis.Our results show that Jun proteins (pc-Jun and JunD) influence carcinogenesis and tumour progression, suggesting a significant role as prognostic predictors in human ovarian carcinoma.