Two-dimensional hybrid mesoporous Fe2O3-graphene nanostructures: a highly active and reusable peroxidase mimetic toward rapid, highly sensitive optical detection of glucose.
Two-dimensional hybrid mesoporous Fe2O3-graphene nanostructures: a highly active and reusable peroxidase mimetic toward rapid, highly sensitive optical detection of glucose.
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DOI：
10.1016/j.bios.2013.09.029
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发表时间：
2014-02
影响因子：
12.6
通讯作者：
Zhicai Xing;Jingqi Tian;Abdullah M. Asiri;A. Qusti;A. O. Al-Youbi;Xuping Sun
中科院分区：
文献类型：
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作者：
Zhicai Xing;Jingqi Tian;Abdullah M. Asiri;A. Qusti;A. O. Al-Youbi;Xuping Sun
在本文中，首次开发了二维杂化介孔fe2o3 -石墨烯（mFe2O3 - G）纳米结构作为过氧化物酶模拟物，其催化活性优于mFe2O3， G和先前报道的铁基过氧化物酶模拟物。高表面积的mfe2o3不仅提供了大量的催化活性位点，而且有利于3,3,5,5-四甲基联苯胺（TMB）和h2o2向G表面扩散。另一方面，G富π，有利于TMB在这些孔隙内的吸附和富集。这些协同效应导致了催化性能的极大提高。在此基础上，开发了一种简单、快速、高灵敏度和选择性的葡萄糖光学检测器，并在缓冲溶液中进行了验证，检测限很低，为0.5 μM。此外，该纳米传感器可重复使用，也可用于稀释血清中的葡萄糖检测。
In this article, for the first time, two-dimensional hybrid mesoporous Fe2O3–graphene (mFe2O3–G) nanostructures were developed as a peroxidase mimetic with catalytic activities superior to those of mFe2O3, G, and previously reported Fe-based peroxidase mimetics. The high-surface-area mFe2O3not only offers a large number of catalytically active sites, but also facilitates the diffusion of 3,3,5,5-tetramethylbenzidine (TMB) and H2O2toward G surface. On the other hand, G is π-rich and thus favors the adsorption and enrichment of TMB within these pores. These synergistic effects lead to highly improved catalytic performances. Based on these findings, a simple, rapid, and highly sensitive and selective optical detector of glucose has been developed and demonstrated in buffer solution with a pretty low detection limit of 0.5 μM. In addition, this nanosensor is reusable and can also be used for glucose detection in diluted serum.