The Effects of 30% and 60% Xenon Inhalation on Pial Vessel Diameter and Intracranial Pressure in Rabbits
The Effects of 30% and 60% Xenon Inhalation on Pial Vessel Diameter and Intracranial Pressure in Rabbits
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%20效果%20of%2030%%20和%2060%%20氙%20吸入%20对%20Pial%20血管%20直径%20和%20颅内%20压力%20in%20兔
作者：
T. Fukuda;Harumi Nakayama;K. Yanagi;T. Mizutani;M. Miyabe;N. Ohshima;H. Toyooka
氙可增加脑血流量和颅内压（ICP）。为了评价氙气对脑循环的影响，我们测量了软脑膜血管直径的变化，二氧化碳反应性，和颅内压在氙气吸入家兔。在家兔（n = 6）中建立氙的最低肺泡麻醉浓度（MAC）。通过使用颅窗模型，测量30%和60%氙吸入组和时间对照组（n = 15）的软脑膜血管直径。在30%和60%氙吸入期间记录ICP、平均动脉血压和心率（n = 5）。在低碳酸血症和高碳酸血症条件下测量60%氙组和对照组（n = 14）的软脑膜血管直径。氙的MAC为85%。氙（0.35和0.7MAC）使小动脉和小静脉分别扩张10%和18%及2%和4%（P < 0.05）。小动脉扩张较小静脉明显。在氙吸入过程中，ICP、平均动脉血压和心率没有变化。氙气组和对照组之间未观察到CO2反应性差异（P = 0.79）。百分之六十的氙（0.7 MAC）扩张脑血管，但小静脉的变化很小。氙气没有增加颅内压，并保留了脑血管的CO2反应性。
Xenon may increase cerebral blood flow and intracranial pressure (ICP). To evaluate the effects of xenon on brain circulation, we measured pial vessel diameter changes, CO2 reactivity, and ICP during xenon inhalation in rabbits. Minimum alveolar anesthetic concentration (MAC) for xenon was established in rabbits (n = 6). By using a cranial window model, pial vessel diameters were measured at 30% and 60% xenon inhalation and in time control groups (n = 15). ICP, mean arterial blood pressure, and heart rate were recorded during 30% and 60% xenon inhalation (n = 5). Pial vessel diameters were measured during hypocapnia and hypercapnia conditions in 60% Xenon and Control groups (n = 14). MAC for xenon was 85%. Xenon (0.35 and 0.7 MAC) dilated the arterioles (10% and 18%, respectively) and venules (2% and 4%, respectively) (P < 0.05). Dilation of arterioles was more prominent than that of venules. ICP, mean arterial blood pressure, and heart rate did not change during xenon inhalation. No difference in CO2 reactivity was observed between Xenon and Control groups (P = 0.79). Sixty percent xenon (0.7 MAC) dilated brain vessels, but venule changes were small. Xenon did not increase ICP and preserved CO2 reactivity of the brain vessels.