Vitamin D, Adiposity, and Calcified Atherosclerotic Plaque in African-Americans
Vitamin D, Adiposity, and Calcified Atherosclerotic Plaque in African-Americans
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DOI：
10.1210/jc.2009-1797
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发表时间：
2010-03-01
影响因子：
5.8
通讯作者：
Divers, Jasmin
中科院分区：
文献类型：
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作者：
Freedman, Barry I.;Wagenknecht, Lynne E.;Divers, Jasmin
背景：据报道，循环中的25-羟基维生素D和内脏肥胖之间存在负相关。维生素D水平对动脉粥样硬化的影响尚不清楚。目的：本研究的目的是测试维生素D、肥胖、骨密度和非洲裔美国人动脉粥样硬化之间的关系。设计：测量循环中的25-羟基维生素D、1，25二羟维生素D、完整的PTH、C反应蛋白和计算机断层扫描衍生的钙化动脉粥样硬化斑块（CP）、骨密度和脂肪体积。设置：检查在一个单一的门诊一般临床研究中心visit.Subjects：340非裔美国人与2型糖尿病进行了评估。平均+/- SD年龄为55.6 ± 9.6岁，糖尿病病程为10.6 ± 8.3年，肾小球滤过率为1.6 ± 0.5 ml/sec，体重指数为35.6 ± 8.7 kg/m2，25-羟维生素D浓度为50.4 ± 30.5 nmol/L。检测生物标志物与心包、内脏、肌肉和皮下脂肪组织;胸椎和腰椎骨密度;主动脉、冠状动脉和颈动脉CP的相关性。结果如下：校正年龄、性别、体重指数、糖化血红蛋白和肾小球滤过率后，25-羟基维生素D与内脏型肥胖呈负相关（P = 0.009）与颈动脉CP、主动脉CP呈正相关（P值分别为0.013和0.014），但与冠状动脉CP或骨密度无关。我们证实了维生素D与非裔美国糖尿病患者内脏肥胖之间存在负相关。此外，在非裔美国人中，25-羟基维生素D与主动脉和颈动脉CP之间存在正相关。补充维生素D以提高血清25-羟基维生素D水平对非洲裔美国人动脉粥样硬化的影响尚不清楚。需要进行前瞻性试验来确定补充维生素D对该种族人群心血管的影响。（临床内分泌代谢杂志95：1076-1083，2010）
Context: Inverse associations are reported between circulating 25-hydroxyvitamin D and visceral adiposity. The effects of vitamin D levels on atherosclerosis are unknown.Objective: The objective of this study was to test for relationships between vitamin D, adiposity, bone density, and atherosclerosis in African-Americans.Design: Circulating 25-hydroxyvitamin D, 1,25 dihydroxyvitamin D, intact PTH, C-reactive protein and computed tomography-derived calcified atherosclerotic plaque (CP), bone density, and fat volumes were measured.Setting: Examinations were performed at a single outpatient general clinical research center visit.Subjects: Three hundred forty African-Americans with type 2 diabetes were evaluated. Mean +/- SD age was 55.6 +/- 9.6 yr, diabetes duration 10.6 +/- 8.3 yr, glomerular filtration rate 1.6 +/- 0.5 ml/sec, body mass index 35.6 +/- 8.7 kg/m(2), and 25-hydroxyvitamin D concentration 50.4 +/- 30.5 nmol/liter.Main Outcome Measure: Biomarkers were tested for association with pericardial, visceral, im, and sc adipose tissues; thoracic and lumbar vertebral bone density; and aorta, coronary, and carotid artery CP. Results: Adjusting for age, gender, body mass index, glycosylated hemoglobin, and glomerular filtration rate, 25-hydroxyvitamin D was negatively associated with visceral adiposity (P = 0.009) and positively associated with carotid artery CP and aorta CP (P = 0.013 and 0.014, respectively) but not with coronary artery CP or bone density.Conclusions: We confirmed an inverse association between vitamin D and visceral adiposity in African-Americans with diabetes. In addition, positive associations exist between 25-hydroxyvitamin D and aorta and carotid artery CP in African-Americans. The effects of supplementing vitamin D to raise the serum 25-hydroxyvitamin D level on atherosclerosis in African-Americans are unknown. Prospective trials are needed to determine the cardiovascular effects of supplemental vitamin D in this ethnic group. (J Clin Endocrinol Metab 95: 1076-1083, 2010)