RAPID REPORT: Dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese rats
RAPID REPORT: Dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese rats
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快速报告：怀孕前的饮食干预逆转了肥胖大鼠雄性后代的代谢程序
DOI：
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
P. Nathanielsz
中科院分区：
文献类型：
--
作者：
E. Zambrano;P. Martínez‐Samayoa;G. L. Rodríguez;P. Nathanielsz
在发展中国家和发达国家，涉及育龄妇女的肥胖症正在急剧增加。母体肥胖和伴随的高能量致肥胖饮食（MO）摄入之前和整个怀孕和哺乳期计划后代的生理系统易受改变的碳水化合物和脂质代谢。母体肥胖诱导的编程结果是否可以通过在受孕前开始改变饮食摄入来逆转，这仍然是一个具有生理和临床重要性的未回答问题。我们通过从断奶到繁殖90天后以及整个妊娠和哺乳期用高脂肪饮食喂养雌性大鼠来诱导孕前母体肥胖。饮食干预组（DINT）的MO女性被转移到正常的食物交配前1个月。对照组在整个过程中接受正常饲料。研究了雄性后代。后代出生体重相似。在出生后第21天的脂肪量，血清甘油三酯，瘦素和胰岛素在MO后代升高，并通过DINT正常化。在出生后第120天，MO后代的血糖、胰岛素和稳态模型评估（HOMA）增加;葡萄糖恢复，HOMA部分逆转至正常。在出生后150天，MO的脂肪量增加，DINT部分逆转。在出生后150天，脂肪细胞的大小增加MO。DINT部分逆转了脂肪细胞大小的这些差异。我们相信这是第一个研究显示了母体肥胖对后代代谢表型的不良代谢影响的可逆性，并且结果和可逆性因受影响的组织而异。
Obesity involving women of reproductive years is increasing dramatically in both developing and developed nations. Maternal obesity and accompanying high energy obesogenic dietary (MO) intake prior to and throughout pregnancy and lactation program offspring physiological systems predisposing to altered carbohydrate and lipid metabolism. Whether maternal obesity‐induced programming outcomes are reversible by altered dietary intake commencing before conception remains an unanswered question of physiological and clinical importance. We induced pre‐pregnancy maternal obesity by feeding female rats with a high fat diet from weaning to breeding 90 days later and through pregnancy and lactation. A dietary intervention group (DINT) of MO females was transferred to normal chow 1 month before mating. Controls received normal chow throughout. Male offspring were studied. Offspring birth weights were similar. At postnatal day 21 fat mass, serum triglycerides, leptin and insulin were elevated in MO offspring and were normalized by DINT. At postnatal day 120 serum glucose, insulin and homeostasis model assessment (HOMA) were increased in MO offspring; glucose was restored, and HOMA partially reversed to normal by DINT. At postnatal day 150 fat mass was increased in MO and partially reversed in DINT. At postnatal day 150, fat cell size was increased by MO. DINT partially reversed these differences in fat cell size. We believe this is the first study showing reversibility of adverse metabolic effects of maternal obesity on offspring metabolic phenotype, and that outcomes and reversibility vary by tissue affected.
DOI：
10.1073/pnas.95.2.741
发表时间：
1998-01-20
影响因子：
11.1
作者：
Elmquist, JK;Ahima, RS;Saper, CB
通讯作者：
Saper, CB
影响因子：
2.5
作者：
Nathanielsz, PW
通讯作者：
Nathanielsz, PW