Expression of nitric oxide synthase-2 in cutaneous squamous cell carcinoma of the head and neck
Expression of nitric oxide synthase-2 in cutaneous squamous cell carcinoma of the head and neck
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DOI：
10.1054/bjom.2001.0680
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发表时间：
2002-06-01
影响因子：
1.8
通讯作者：
Tant, S
中科院分区：
文献类型：
--
作者：
Brennan, PA;Umar, T;Tant, S
一氧化氮（NO）在血管生成中具有关键作用。一氧化氮合酶（NOS2）的表达在基底细胞皮肤癌中下调，但我们知道没有研究调查其在更具侵袭性的鳞状细胞皮肤癌中的表达。本研究采用免疫组化方法检测了37例头颈部皮肤鳞状细胞癌中NOS 2的表达。NOS 2表达位于表皮基底细胞层的细胞中，但在肿瘤上皮中显著增加。NOS 2表达与肿瘤大小和肿瘤分化程度无相关性。这些肿瘤中NO浓度的升高可能为它们比生长缓慢的基底细胞癌更具侵袭性提供了一种解释。(C)2002年英国口腔颌面外科医师协会。
Nitric oxide (NO) has a pivotal role in angiogenesis. The expression of NO synthase (NOS2) is down-regulated in basal cell skin cancer but we know of no studies that have investigated its expression in the more aggressive squamous cell skin carcinoma. This immunohistochemical study assessed NOS2 expression in 37 cases of head and neck squamous cell skin carcinoma. NOS2 expression was located in cells of the basal cell layer of epidermis, but was significantly increased in tumour epithelium. No correlations were found between NOS2 expression and tumour size or degree of tumour differentiation. The raised NO concentrations in these tumours may provide one explanation for their more aggressive behaviour than that of the slower-growing basal cell carcinoma. (C) 2002 The British Association of Oral and Maxillofacial Surgeons.