Inhibition of prostate ductal morphogenesis by retinoic acid.
Inhibition of prostate ductal morphogenesis by retinoic acid.
复制标题
视黄酸抑制前列腺导管形态发生。
DOI：
10.1097/00005392-199709000-00074
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Bushman,W
中科院分区：
文献类型：
--
作者：
Seo,R;McGuire,M;Chung,M;Bushman,W
PurposeTo examine the effect of retinoic acid on prostate ductal morphogenesis.Materials and MethodsNewborn male Balb/C mice were injected with 25 mg./kg. all-trans retinoic acid or vehicle alone. Animals were sacrificed at 60 days of age and prostate ductal morphology was quantitatively assessed by microdissection. Total prostate DNA was quantitated by DPA assay.ResultsThe greatest effect was seen in the ventral prostate. Retinoic acid treated animals showed a 20% decrease in mean number of branch-points (p = 0.0006) with a corresponding 13% decrease in duct tips (p = 0.026). The combined ventral and dorsal prostate showed an effect with a 12% decrease in ductal branchpoints (p = 0.048). There was no effect on animal or organ weight and no effect on DNA content within the prostate. There was no difference in the prostate histology of treated and control animals.ConclusionRetinoic acid administration in the newborn period inhibits mouse prostate ductal morphogenesis. This effect appears independent of an inhibition of overall growth.
