Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model.
Extracorporeal Shock Wave Therapy Promotes Osteogenic Differentiation in a Rabbit Osteoporosis Model.
复制标题
体外冲击波治疗促进兔骨质疏松模型的成骨分化。
DOI：
10.3389/fendo.2021.627718
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发表时间：
2021
影响因子：
5.2
通讯作者：
Chen B
中科院分区：
文献类型：
--
作者：
Li B;Wang R;Huang X;Ou Y;Jia Z;Lin S;Zhang Y;Xia H;Chen B
Extracorporeal shock wave therapy (ESWT) has been identified to accelerate bone formation. However, detailed mechanism has not been fully explained. In this study, we found that ESWT promoted osteoblast formation in vitro. Local ESW treatment of femur increased bone formation in vivo. Furthermore, changing the density or frequency of energy, there was no statistical difference in osteogenic differentiation. Therapeutically, local ESW therapy relieved bone loss and increased the number of bone trabecular in a rabbit osteoporosis model and promoted endogenous levels of SMAD2 protein expression. Thus, ESWT may be a potential therapy by promoting osteoblast maturation through TGF-β/SMAD2 pathway.
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影响因子：
--
作者：
Zhang HW;Wang EW;Li LX;Yi SH;Li LC;Xu FL;Wang DL;Wu YZ;Nian WQ
通讯作者：
Nian WQ
影响因子：
2.6
作者：
Xie K;Mao Y;Qu X;Dai K;Jia Q;Zhu Z;Yan M
通讯作者：
Yan M
影响因子：
23.4
作者：
Lu, Zhihua;Lin, Guiting;Lue, Tom F.
通讯作者：
Lue, Tom F.
影响因子：
--
作者：
Simplicio, Claudio Lopes;Purita, Joseph;Lana, Jose Fabio Santos Duarte
通讯作者：
Lana, Jose Fabio Santos Duarte
影响因子：
2.7
作者：
Chaussy, C.;Eisenberger, F.;Forssmann, B.
通讯作者：
Forssmann, B.