LYSIS GENE-EXPRESSION OF RNA PHAGE MS2 DEPENDS ON A FRAMESHIFT DURING TRANSLATION OF THE OVERLAPPING COAT PROTEIN GENE
LYSIS GENE-EXPRESSION OF RNA PHAGE MS2 DEPENDS ON A FRAMESHIFT DURING TRANSLATION OF THE OVERLAPPING COAT PROTEIN GENE
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DOI：
10.1038/295035a0
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发表时间：
1982-01-01
期刊：
影响因子：
64.8
通讯作者：
VANDUIN, J
中科院分区：
文献类型：
--
作者：
KASTELEIN, RA;REMAUT, E;VANDUIN, J
MS2 RNA的裂解顺反子的翻译需要核糖体的移码阅读上游外壳蛋白mRNA。核糖体的异相部分终止于刚好在裂解顺反子之前的2个无义密码子中的任一个。终止之后是在裂解蛋白信息的起始密码子处的起始。
Translation of the lysis cistron of MS2 RNA requires a frameshift of ribosomes reading the upstream coat protein mRNA. The out-of-phase fraction of ribosomes terminates at either 1 of 2 nonsense codons just preceding the lysis cistron. Termination is followed by initiation at the start codon of the lysis protein message.