Genome wide analysis reveals association of a FTO gene variant with epigenetic changes
Genome wide analysis reveals association of a FTO gene variant with epigenetic changes
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DOI：
10.1016/j.ygeno.2011.12.007
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发表时间：
2012-03-01
期刊：
影响因子：
4.4
通讯作者：
Schioth, Helgi B.
中科院分区：
文献类型：
--
作者：
Almen, Markus Sallman;Jacobsson, Josefin A.;Schioth, Helgi B.
FTO基因的变体与肥胖有很强的关联，但这种关联背后的机制仍不清楚。我们确定了47名女性青春期前血液中的全基因组DNA甲基化谱。我们确定了与基因KARS、TERF2IP、DEXI、MSI1、STON 1和BCAS 3相关的位点，这些位点在FTO风险等位基因（rs9939609）携带者中具有显著差异的甲基化水平。此外，我们还发现了20个与肥胖相关的差异甲基化位点。我们的研究结果表明，FTO肥胖风险等位基因的影响可能是通过表观遗传变化介导的。此外，这些位点可能被证明是了解肥胖及其合并症的有价值的生物标志物。(C)2011 Elsevier Inc. All rights reserved.
Variants of the FTO gene show strong association with obesity, but the mechanisms behind this association remain unclear. We determined the genome wide DNA methylation profile in blood from 47 female preadolescents. We identified sites associated with the genes KARS, TERF2IP, DEXI, MSI1,STON1 and BCAS3 that had a significant differential methylation level in the carriers of the FTO risk allele (rs9939609). In addition, we identified 20 differentially methylated sites associated with obesity. Our findings suggest that the effect of the FTO obesity risk allele may be mediated through epigenetic changes. Further, these sites might prove to be valuable biomarkers for the understanding of obesity and its comorbidites. (C) 2011 Elsevier Inc. All rights reserved.