Alterations in Hub Organization in the White Matter Structural Network in Toddlers with Autism Spectrum Disorder: A 2-Year Follow-Up Study
Alterations in Hub Organization in the White Matter Structural Network in Toddlers with Autism Spectrum Disorder: A 2-Year Follow-Up Study
复制标题
患有自闭症谱系障碍的幼儿白质结构网络中枢组织的改变：一项为期 2 年的随访研究
DOI：
10.1002/aur.1983
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发表时间：
2018
期刊：
影响因子：
4.7
通讯作者：
Ke XiaoYan
中科院分区：
文献类型：
--
作者：
Qian Lu;Wang Yao;Chu KangKang;Li Yun;Xiao ChaoYong;Xiao Ting;Xiao Xiang;Qiu Ting;Xiao YunHua;Fang Hui;Ke XiaoYan
目前对自闭症谱系障碍（ASD）幼儿全脑白色物质（WM）结构网络中枢纽的纵向发育模式知之甚少。本研究利用扩散张量成像（DTI）和确定性纤维束成像，在基线（时间1）和2年随访（时间2）时绘制了37名ASD幼儿和27名年龄、性别和发育商匹配的2-3岁发育迟缓（DD）幼儿的WM结构网络。此外，应用图论方法研究这些患者在两个时间点的网络枢纽的变化。结果显示，2年后，与对照组相比，ASD受试者中确定了17个枢纽，包括13个与基线相比没有变化的枢纽和4个新确定的枢纽。此外，右额中回，右颞叶，左正中扣带回和双侧楔前叶的枢纽的属性的改变与ASD患者的行为数据的改变显著相关。这些结果表明，在2-5岁阶段，ASD儿童的网络枢纽分布相对稳定，差异较小。ASD中上述五个区域的异常发育模式可能导致这种疾病的社会和非社会特征异常。Autism Res 2018，11：1218-1228。© 2018 International Society for Autism Research，Wiley Periodicals，Inc.Lay SummaryThis work studied the longitudinal developmental patterns of hubs in the whole‐brain白色matter（WM）structural network among toddlers with autism spectrum disorder（ASD）.这项研究的结果可能有助于理解ASD中枢组织的异常如何解释患者的行为缺陷，并可能为疾病诊断和随后监测ASD患者的进展和治疗效果提供潜在的生物标志物。
Little is currently known about the longitudinal developmental patterns of hubs in the whole‐brain white matter (WM) structural networks among toddlers with autism spectrum disorder (ASD). This study utilized diffusion tensor imaging (DTI) and deterministic tractography to map the WM structural networks in 37 ASD toddlers and 27 age‐, gender‐ and developmental quotient‐matched controls with developmental delay (DD) toddlers aged 2–3 years old at baseline (Time 1) and at 2‐year follow‐up (Time 2). Furthermore, graph‐theoretical methods were applied to investigate alterations in the network hubs in these patients at the two time points. The results showed that after 2 years, 17 hubs were identified in the ASD subjects compared to the controls, including 13 hubs that had not changed from baseline and 4 hubs that were newly identified. In addition, alterations in the properties of the hubs of the right middle frontal gyrus, right insula, left median cingulate gyri, and bilateral precuneus were significantly correlated with alterations in the behavioral data for ASD patients. These results indicated that at the stage of 2–5 years of age, ASD children showed distributions of network hubs that were relatively stable, with minor differences. Abnormal developmental patterns in the five areas mentioned above in ASD may contribute to abnormalities in the social and nonsocial characteristics of this disorder.Autism Res2018, 11: 1218–1228. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryThis work studied the longitudinal developmental patterns of hubs in the whole‐brain white matter (WM) structural network among toddlers with autism spectrum disorder (ASD). The findings of this study could have implications for understanding how the abnormalities in hub organization in ASD account for behavioral deficits in patients and may provide potential biomarkers for disease diagnosis and the subsequent monitoring of progression and treatment effects for patients with ASD.