Diffusion Tensor Imaging Detects Rarefaction of Optic Radiation in Glaucoma Patients
Diffusion Tensor Imaging Detects Rarefaction of Optic Radiation in Glaucoma Patients
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DOI：
10.1016/j.acra.2011.01.014
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发表时间：
2011-06-01
影响因子：
4.8
通讯作者：
Doerfler, Arnd
中科院分区：
文献类型：
--
作者：
Engelhorn, Tobias;Michelson, Georg;Doerfler, Arnd
原理和目的：扩散张量成像（DTI）可以描述稀疏的光纤。材料与方法：应用31位高场强磁共振扫描仪对50例青光眼患者和50例年龄匹配的健康对照者进行检查。纤维束的体积呈现使用半定量的方法来评估稀疏和结果与视神经萎缩的程度和减少的空间-时间对比敏感度的视网膜使用已建立的眼科examinations.Results：22青光眼患者（44%）表现出显着稀疏的视辐射：体积减少到67 +/- 16%与对照组相比。因此，昏迷性视神经萎缩分期与DTI衍生的稀疏视放射的存在相关（Kendall tau-b 0.272，P = 0.016）。此外，青光眼患者中影响视辐射的脑微血管病变显著高于对照组（10例患者与2例患者相比，P <0.05）。在青光眼性视神经萎缩患者中，有顺行性的，最有可能是因为视神经辐射内的微血管病变，视辐射的逆行跨神经元稀疏，可以使用DTI在体内进行评估，与已建立的眼科检查具有良好的相关性。
Rationale and Objectives: Diffusion tensor imaging (DTI) can depict rarefaction of the optical fibres. Hence, we applied DTI to assess pathological changes of the optic radiation in glaucoma patients.Materials and Methods: Fifty glaucoma patients and 50 healthy age-matched controls were examined by a 31 high-field magnetic resonance scanner. Fiber tracts were volume rendered using a semiquantitative approach to assess rarefaction and results were correlated with the extent of optic nerve atrophy and reduced spatial-temporal contrast sensitivity of the retina using established ophthalmological examinations.Results: Twenty-two glaucoma patients (44%) showed significant rarefaction of the optic radiation: the volume was reduced to 67 +/- 16% compared with controls. Hereby, the glaucomatous optic nerve atrophy stage correlated with the presence of DTI-derived rarefied optic radiation (Kendall tau-b 0.272, P = .016). Aside, cerebral microangiopathy affecting the optic radiation was significantly higher among glaucoma patients compared to controls (10 patients compared with 2 patients, P < .05).Conclusion: In patients with glaucomatous optic nerve atrophy, there is anterograde and-most likely because of microangiopathic lesions within the optic radiation-retrograde transneuronal rarefaction of the optic radiation that can be assessed in vivo using DTI with good correlation to established ophthalmological examinations.