MULTIFRACTAL RADIOGRAPHIC ANALYSIS OF OSTEOPOROSIS
MULTIFRACTAL RADIOGRAPHIC ANALYSIS OF OSTEOPOROSIS
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DOI：
10.1118/1.597390
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发表时间：
1994-04-01
期刊：
影响因子：
3.8
通讯作者：
FAVUS, M
中科院分区：
文献类型：
--
作者：
CALIGIURI, P;GIGER, ML;FAVUS, M
骨质疏松症的一个重要并发症是骨折。骨结构的改变，以及骨量减少，有助于骨质疏松症骨折的倾向。目前仅测量骨量的方法显示骨折患者的测量结果与未骨折患者的测量结果有相当大的重叠。我们的目的是开发一种非侵入性的方法来评估平片X光片上的骨结构，以更好地预测骨质疏松症的骨折风险。感兴趣区域（ROI）从数字化腰椎侧位X线片的43例患者正在骨质疏松症诊所。使用表面积法估计这些ROI的分形维数。采用受试者工作特征（ROC）分析评价分形维数区分脊柱其他部位骨折病例与非骨折病例的能力。将这些结果与使用骨矿物质密度（BMD）测量（骨量）的相同患者的ROC分析进行比较。使用分形维数（0.87）获得的A1（ROC曲线下面积）值显著大于使用BMD（0.58）获得的A1（ROC曲线下面积）值，表明使用分形维数获得的测试性能更好。因此，计算机化的影像学方法来评估骨结构，如分形分析，可能有助于更好地确定骨质疏松症的骨折风险。
An important complication of osteoporosis is fracture. Alteration in bone structure, as well as decreased bone mass, contribute to the tendency to fracture in osteoporosis. Current methods that measure bone mass alone show substantial overlap of the measurements of osteoporotic patients who fracture with those that do not. Our aim is to develop noninvasive methods of evaluating bone structure on plain film radiographs to better predict fracture risk in osteoporosis. Regions of interest (ROIs) were selected from digitized lateral lumbar spine radiographs of 43 patients being seen in an osteoporosis clinic. The fractal dimension of these ROIs was estimated using a surface area method. The ability of fractal dimension to distinguish between cases that had fracture elsewhere in the spine from those that did not, was evaluated using receiver operating characteristic (ROC) analysis. These results were compared with ROC analysis for these same patients using bone mineral density (BMD) measurements (bone mass). Significantly larger A, (area under ROC curve) values were obtained using fractal dimension (0.87) than from using BMD (0.58), indicating a better test performance using fractal dimension. Therefore, computerized radiographic methods to evaluate bone structure, such as fractal analysis, may be helpful in better determining fracture risk in osteoporosis.