Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
复制标题
人类共生多形拟杆菌合成 2-酮-3-脱氧-D-甘油-D-半乳壬酸 (KDN)。
DOI：
10.1016/j.chembiol.2008.08.005
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发表时间：
2008
影响因子：
--
通讯作者：
Dunaway-Mariano,Debra
中科院分区：
文献类型：
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作者：
Wang,Liangbing;Lu,Zhibing;Allen,KarenN;Mariano,PatrickS;Dunaway-Mariano,Debra
人类肠道的正常功能取决于其细菌共生体，其中最主要的是属于PhylumBacteroidetes。多形拟杆菌（Bacteroides thetaiotaomicrons）是一种重要的人类肠道共生菌，也是一种功能多样的嗜糖菌。由8个CP基因座编码的CP的结构决定是从分子水平上理解该生物体适应机制的关键。在此，我们报告了基于生物信息学的发现和化学论证的生物合成途径，形成和胞苷化2-酮-3-脱氧-D-甘油-D-半乳糖-壬酸（KDN），最有可能包含在CP编码的B。thetaiotaomicronCP基因座7。
The proper functioning of the human intestine is dependent on its bacterial symbionts, the most predominant of which belong to the PhylumBacteroidetes. These bacteria are known to use variable displays of multiple capsular polysaccharides (CPs) to aid in their survival and foraging within the intestine.Bacteroides thetaiotaomicronis a prominent human gut symbiont and a remarkably versatile glycophile. The structure determination of the CPs, encoded by the eight CP loci, is the key to understanding the mechanism of this organism's adaptation on a molecular level. Herein, we report the bioinformatics-based discovery and chemical demonstration of a biosynthetic pathway that forms and cytidylates 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), most likely for inclusion in the CP encoded byB. thetaiotaomicronCP locus 7.