Diffusional transport in responding lipid membranes
Diffusional transport in responding lipid membranes
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DOI：
10.1039/b901737b
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发表时间：
2009-08
期刊：
影响因子：
3.4
通讯作者：
E. Sparr;Christoffer Åberg;Peter Nilsson;H. Wennerström
中科院分区：
文献类型：
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作者：
E. Sparr;Christoffer Åberg;Peter Nilsson;H. Wennerström
脂质膜的扩散运输是非常复杂的，包括几个平行的运输过程。对于响应的脂质膜来说，膜环境的微小变化会导致膜结构的重大变化，这是典型的。在多层膜中，响应可以表现为非均匀膨胀和相变。膜结构的变化深刻地影响了分子环境，从而影响了局部扩散特性。这种反馈机制产生非线性输运行为，其中外部梯度可以用作调节膜屏障特性的一种开关。这种膜的动态和静态特性之间的耦合构成了这篇综述的基础，该综述描述了响应膜的基本概念，并举例说明了它可以应用的一些例子。响应膜的一个主要特征是非线性输运行为可以由引起膜相变的梯度引起。这是对存在渗透梯度的脂质膜的说明。这些原理也适用于角质层（人体皮肤的上层）的屏障，它可以解释所谓的闭塞效应和皮肤表面“酸性地幔”的形成。
Diffusional transport across lipid membranes can be highly complex and include several parallel transport processes. It is typical for the responding lipid membrane that small changes in the membrane environment can lead to major changes in membrane structure. In a multilayer membrane, the response can lie in heterogeneous swelling and phase transformations. The changes in membrane structure profoundly affect the molecular environment and thus the local diffusion properties. This feedback mechanism generates non-linear transport behaviour where an external gradient can be used as a kind of switch to regulate the membrane barrier properties. This coupling between the dynamic and the static properties of the membrane forms the basis for this review paper that describes the basic concepts of responding membranes and illustrates some examples of where it can be applied. A major feature of responding membranes is that non-linear transport behaviour can be induced by the gradients that cause phase transformation in the membrane. This is illustrated for a lipid membrane in the presence of an osmotic gradient. The principles are also applied to the barrier of stratum corneum, the upper layer of the human skin, where it can provide an explanation for the so-called occlusion effect and the formation of the “acidic mantle” of the skin surface.