Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model.
Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model.
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DOI：
10.1155/2016/5679040
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发表时间：
2016
影响因子：
--
通讯作者：
Ito HO
中科院分区：
文献类型：
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作者：
Tamaki N;Orihuela-Campos RC;Fukui M;Ito HO
伤口愈合过程试图恢复受伤组织的完整性和功能。此外，促炎细胞因子、生长因子和氧化应激在伤口愈合中起重要作用。本研究的目的是确定富氢水摄入是否诱导大鼠腭组织Nrf2/抗氧化防御通路的激活，从而降低全身氧化应激和促炎细胞因子水平，促进愈合相关基因的表达。在口腔腭区造圆形切除创面，观察创面愈合过程。老鼠被分成两组，一组喝富氢水，一组喝蒸馏水。饮用富氢水后，与对照组相比，腭创面愈合过程加快。分子氢上调Nrf2通路，通过激活抗氧化活性降低全身氧化应激。此外，富氢水摄入降低了大鼠腭组织中促炎细胞因子水平，促进了愈合相关因子的表达。综上所述，富氢水摄入通过激活Nrf2/抗氧化防御途径表现出多种有益作用。本研究的结果支持了口服富氢水通过减少氧化应激和炎症反应有利于伤口愈合过程的假设。
The wound healing process attempts to restore the integrity and function of the injured tissue. Additionally, proinflammatory cytokines, growth factors, and oxidative stress play important roles in wound healing. The aim of this study was to determine whether hydrogen-rich water intake induces the activation of the Nrf2/antioxidant defense pathway in rat palatal tissue, thereby reducing systemic oxidative stress and proinflammatory cytokine levels and promoting healing-associated genes. A circular excisional wound was created in the oral palatal region, and the wound healing process was observed. The rats were divided into two experimental groups in which either hydrogen-rich water or distilled water was consumed. In the drinking hydrogen-rich water, the palatal wound healing process was accelerated compared to that in the control group. As molecular hydrogen upregulated the Nrf2 pathway, systemic oxidative stresses were decreased by the activation of antioxidant activity. Furthermore, hydrogen-rich water intake reduced proinflammatory cytokine levels and promoted the expression of healing-associated factors in rat palatal tissue. In conclusion, hydrogen-rich water intake exhibited multiple beneficial effects through activation of the Nrf2/antioxidant defense pathway. The results of this study support the hypothesis that oral administration of hydrogen-rich water benefits the wound healing process by decreasing oxidative stress and inflammatory responses.