Oxytocin can hinder trust and cooperation in borderline personality disorder
Oxytocin can hinder trust and cooperation in borderline personality disorder
复制标题
DOI：
10.1093/scan/nsq085
复制
发表时间：
2011-10-01
影响因子：
4.2
通讯作者：
Hollander, Eric
中科院分区：
文献类型：
--
作者：
Bartz, Jennifer;Simeon, Daphne;Hollander, Eric
我们研究了鼻内催产素（OXT）对边缘型人格障碍（BPD）患者信任与合作的影响，BPD是一种以人际关系不稳定和合作困难为特征的疾病。尽管在健康成人中的研究表明鼻内OXT增加信任，但BPD个体可能对外源性OXT表现出改变的反应，因为OXT对信任和亲社会行为的影响可能因人们拥有的关系表征和期望和/或BPD中OXT系统功能改变而异。BPD和对照组受试者接受鼻内OXT治疗，并与伴侣进行社交困境游戏。结果表明，OXT在BPD参与者中产生了不同的效果，降低了信任和合作反应的可能性。其他分析集中在BPD和对照组参与者的依恋焦虑和回避的个体差异表明，这些不同的影响是由焦虑的依恋，拒绝敏感的参与者。这些数据表明，OXT并不均匀促进人类的信任和亲社会行为;事实上，OXT可能会阻碍信任和亲社会行为，这取决于慢性人际不安全感和/或OXT系统中可能的神经化学差异。虽然普遍被称为“爱的激素”，这些数据表明一个更谨慎的答案，谁将受益于OXT的问题。
We investigated the effects of intranasal oxytocin (OXT) on trust and cooperation in borderline personality disorder (BPD), a disorder marked by interpersonal instability and difficulties with cooperation. Although studies in healthy adults show that intranasal OXT increases trust, individuals with BPD may show an altered response to exogenous OXT because the effects of OXT on trust and pro-social behavior may vary depending on the relationship representations and expectations people possess and/or altered OXT system functioning in BPD. BPD and control participants received intranasal OXT and played a social dilemma game with a partner. Results showed that OXT produced divergent effects in BPD participants, decreasing trust and the likelihood of cooperative responses. Additional analyses focusing on individual differences in attachment anxiety and avoidance across BPD and control participants indicate that these divergent effects were driven by the anxiously attached, rejection-sensitive participants. These data suggest that OXT does not uniformly facilitate trust and pro-social behavior in humans; indeed, OXT may impede trust and pro-social behavior depending on chronic interpersonal insecurities, and/or possible neurochemical differences in the OXT system. Although popularly dubbed the 'hormone of love', these data suggest a more circumspect answer to the question of who will benefit from OXT.