SURAMIN PROTECTION OF T-CELLS INVITRO AGAINST INFECTIVITY AND CYTOPATHIC EFFECT OF HTLV-III
SURAMIN PROTECTION OF T-CELLS INVITRO AGAINST INFECTIVITY AND CYTOPATHIC EFFECT OF HTLV-III
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DOI：
10.1126/science.6091268
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
BRODER, S
中科院分区：
文献类型：
--
作者：
MITSUYA, H;POPOVIC, M;BRODER, S
最近发现的逆转录病毒的人类T细胞白血病病毒（HTLV）家族的成员在病因学上与获得性免疫缺陷综合征（AIDS）有关。这种病毒被命名为HTLV-III，对携带OKT 4（辅助诱导物）的T细胞是嗜性的。此外，病毒对这些细胞是致细胞病变的。苏拉明是一种用于治疗罗得西亚锥虫病和盘尾丝虫病的药物，已知它能抑制许多逆转录病毒的逆转录酶。现已发现苏拉明在体外（大鼠H-9细胞）阻断HTLV-III的感染性和致细胞病变作用，其剂量为人类临床可达到的剂量。
A recently discovered member of the human T-cell leukemia virus (HTLV) family of retroviruses has been etiologically linked to the acquired immune deficiency syndrome (AIDS). This virus, which was designated HTLV-III, is tropic for OKT4-bearing (helper-inducer) T cells. Moreover, the virus is cytopathic for these cells. Suramin is a drug used in the therapy of Rhodesian trypanosomiasis and onchocerciasis and it is known to inhibit the reverse transcriptase of a numer of retroviruses. Suramin has now been found to block in vitro [rat H-9 cells] the infectivity and cytopathic effect of HTLV-III at doses that are clinically attainable in human beings.