Ubiquitination and proteolysis in limb and respiratory muscles of patients with chronic obstructive pulmonary disease.
Ubiquitination and proteolysis in limb and respiratory muscles of patients with chronic obstructive pulmonary disease.
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DOI：
10.1513/pats.200906-051js
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发表时间：
2010-02-01
期刊：
影响因子：
--
通讯作者：
Maltais, Francois
中科院分区：
文献类型：
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作者：
Debigare, Richard;Cote, Claude H;Maltais, Francois
与慢性疾病相关的外周肌肉功能障碍无疑是一个日益严重的问题，因为其主要原因之一，慢性阻塞性肺疾病（COPD），进展。其中，肌肉萎缩是建立肌肉功能障碍概念的一个组成部分。肌肉萎缩对患者的临床状态有显著影响，与肺功能受损无关。最近，人们做了大量的努力来增加我们对COPD与肌肉萎缩的发生和发展之间关系的理解。越来越多的证据表明，泛素-蛋白酶体系统，一个ATP依赖的蛋白水解途径，在级联反应中起着至关重要的作用，导致收缩蛋白的降解，从而促进肌肉萎缩的发展。有趣的是，该系统也参与基本的细胞过程，如对低氧血症和肌肉组织再生的反应。在这篇综述中，现有的证据连接的泛素-蛋白酶体系统的活动和细胞事件发生在COPD患者的呼吸和外周肌肉。基于这些信息，读者应该能够理解这一途径在肌肉稳态中的重要作用，并描绘出这一领域即将到来的研究。
Peripheral muscle dysfunction associated with chronic diseases is undeniably a growing problem as one of its main causes, chronic obstructive pulmonary disease (COPD), progresses. Among others, muscle atrophy is one component building the concept of muscle dysfunction. Muscle atrophy has a significant impact on patient clinical status, independent of the impairment in lung function. A lot of effort has been devoted lately to increasing our understanding of the relationship between COPD and the initiation and the development of muscle atrophy. A growing body of evidence is showing that the ubiquitin-proteasome system, an ATP-dependent proteolytic pathway, is playing a crucial role in the cascade leading to degradation of contractile proteins, thus promoting the development of muscle atrophy. Interestingly, this system is also involved in essential cellular processes such as response to hypoxemia and muscle tissue regeneration. In this review, existing evidence linking the activity of the ubiquitin-proteasome system and the cellular events taking place in respiratory and peripheral muscles of patients with COPD are reported. Based on this information, the reader should be able to understand the essential role of this pathway in the context of muscle homeostasis and to picture the coming research in this area.