Design and formulation of nanoemulsions using 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene in combination with linear perfluoro(polyethylene glycol dimethyl ether).
Design and formulation of nanoemulsions using 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene in combination with linear perfluoro(polyethylene glycol dimethyl ether).
复制标题
使用 2-（聚（六氟环氧丙烷））全氟丙基苯与线性全氟（聚乙二醇二甲醚）组合设计和配制纳米乳液。
DOI：
10.1016/j.jfluchem.2014.03.007
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发表时间：
2014
影响因子：
1.9
通讯作者：
Janjic,JelenaM
中科院分区：
文献类型：
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作者：
Mountain,GregoryA;Jelier,BensonJ;Bagia,Christina;Friesen,ChadronM;Janjic,JelenaM
这是第一份将 PFPAE 芳香族缀合物和全氟（聚乙二醇二甲醚）组合并配制为液滴尺寸低于 100 nm 的纳米乳液的报告。全氟聚烷基醚（PFPAE）芳香族共轭物2-（聚（六氟环氧丙烷））全氟丙基苯被用作亲氟-亲水二嵌段（FLD），旨在稳定全氟（聚乙二醇二甲醚）纳米乳液。研究了它对三相（有机/氟/水）纳米乳液中胶体行为的影响。将 FLD 构建体添加到氟相中导致 PFPAE 纳米乳液液滴尺寸减小至 85 nm。制备的纳米乳液表现出较高的胶体稳定性。我们的结果表明，这些材料代表了氟胶体系统设计的可行新方法，具有生物医学和合成应用的潜力。
This is the first report where PFPAE aromatic conjugates and perfluoro(polyethylene glycol dimethyl ether) are combined and formulated as nanoemulsions with droplet size below 100 nm. A perfluoropolyalkylether (PFPAE) aromatic conjugate, 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene, was used as fluorophilic-hydrophilic diblock (FLD) aimed at stabilizing perfluoro(polyethylene glycol dimethyl ether) nanoemulsions. Its effects on colloidal behaviors in triphasic (organic/fluorous/aqueous) nanoemulsions were studied. The addition of FLD construct to fluorous phase led to decrease in PFPAE nanoemulsion droplet size to as low as 85 nm. Prepared nanoemulsions showed high colloidal stability. Our results suggest that these materials represent viable novel approach to fluorous colloid systems design with potential for biomedical and synthetic applications.