Nicotine reduction revisited: science and future directions.
Nicotine reduction revisited: science and future directions.
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DOI：
10.1136/tc.2009.035584
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发表时间：
2010-10
期刊：
影响因子：
5.2
通讯作者：
Zeller M
中科院分区：
文献类型：
--
作者：
Hatsukami DK;Perkins KA;Lesage MG;Ashley DL;Henningfield JE;Benowitz NL;Backinger CL;Zeller M
2009年通过的《家庭吸烟预防和烟草控制法案》（FSPTCA）赋予美国食品和药物管理局监管烟草产品的权力，以及《世界卫生组织烟草控制框架公约》第9-11条，现在有可能对香烟和其他烟草产品中的尼古丁含量进行监管。这两种监管方法都允许为烟草成分（包括尼古丁）制定产品标准。FSPTCA不允许尼古丁含量降至零，尽管FDA有权将尼古丁含量降至非常低的水平，大概不会使人上瘾。将尼古丁含量降低到不会使人上瘾的水平的建议最初是在1994年提出的。减少烟草制品中的尼古丁可能对减少与烟草有关的发病率和死亡率产生深远影响。为了审查这一问题，在美国召开了两次会议，与会者包括不同学科的非烟草业科学家、烟草控制政策制定者和政府机构的代表。本文概述了目前在降低尼古丁含量香烟领域的科学，以及会议成员审议后产生的主要结论和研究和政策建议。
Regulation of nicotine levels in cigarettes and other tobacco products is now possible with the passage of the Family Smoking Prevention and Tobacco Control Act (FSPTCA) in 2009 giving the U.S. Food and Drug Administration authority to regulate tobacco products, and with Articles 9-11 of the World Health Organization Framework Convention on Tobacco Control. Both regulatory approaches allow establishing product standards for tobacco constituents, including nicotine. The FSPTCA does not allow nicotine levels to be decreased to zero, although FDA has the authority to reduce nicotine yields to very low, presumably non-addicting levels. The proposal to reduce levels of nicotine to a level that is non-addicting was originally suggested in 1994. Reduction of nicotine in tobacco products could potentially have a profound impact on reducing tobacco-related morbidity and mortality. To examine this issue, two meetings were convened in the United States with non-tobacco-industry scientists of varied disciplines, tobacco control policy-makers and representatives of government agencies. This article provides an overview of the current science in the area of reduced nicotine content cigarettes and key conclusions and recommendations for research and policy that emerged from the deliberations of the meeting members.