STABILIZATION OF SEA-URCHIN FLAGELLAR MICROTUBULES BY HISTONE-H1
STABILIZATION OF SEA-URCHIN FLAGELLAR MICROTUBULES BY HISTONE-H1
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DOI：
10.1038/360033a0
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发表时间：
1992-11-05
期刊：
影响因子：
64.8
通讯作者：
JOB, D
中科院分区：
文献类型：
--
作者：
MULTIGNER, L;GAGNON, J;JOB, D
复杂的微管组件是真核纤毛和鞭毛的重要组成部分。它们非常稳定，不会受到通常引起聚合物分解的试剂的影响。这种微管稳定性的分子基础尚不清楚，并且与组成性微管蛋白的任何特征无关。在海胆精子鞭毛中，发现轴丝微管被与组蛋白 H1 相同的蛋白质稳定，这一结果定义了该组蛋白的新作用，并为染色质和微管结构的协同进化提供了证据。
Complex microtubule assemblies are essential components of eukaryotic cilia and flagella. They are extremely stable and are not affected by agents that normally induce polymer disassembly. The molecular basis of this microtubular stability is unknown, and it is not related to any feature of the constitutive tubulin. In sea urchin sperm flagella, axonemal microtubules are found to be stabilized by a protein identical to histone H1, a result that defines a new role for this histone and provides evidence for a concerted evolution of chromatin and microtubular structures.