Outpatient screening tests for primary aldosteronism.
Outpatient screening tests for primary aldosteronism.
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原发性醛固酮增多症的门诊筛查试验。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
E. Espiner
中科院分区：
文献类型：
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作者：
P. Dunn;E. Espiner
对五名原发性醛固酮增多症患者和原发性高血压患者的基础血浆醛固酮和肾素浓度以及尿醛固酮排泄量的评估与采用盐皮质激素诱导扩容的抑制试验后的值进行了比较。事实证明，仅依靠基础血浆醛固酮浓度、血浆肾素/醛固酮比值和尿醛固酮排泄量的测量来区分原发性醛固酮增多症患者并不能令人满意。然而，与原发性高血压患者相比，这些患者在每天使用 400 杯氟氢可的松 (florinef) 治疗三天后，血浆醛固酮浓度升高或没有降低。有人提出，基础血浆肾素活性的评估与血浆醛固酮的florinef抑制一起是诊断原发性醛固酮增多症最有效和最方便的门诊筛查程序。
The assessment of basal plasma aldosterone and renin concentrations, and urinary aldosterone excretion has been compared with their values after a suppressive test employing mineralocorticoid induced volume expansion in five patients with primary aldosteronism and in patients with essential hypertension. Reliance upon measurements of basal plasma aldosterone concentration, plasma renin/aldosterone ratio and urine aldosterone excretion alone proved unsatisfactory for distinguishing patients with primary aldosteronism. However these patients, in contrast to those with essential hypertension, showed elevated values or no decrease in plasma aldosterone concentration following three days treatment with 400 mug fludrocortisone (florinef) daily. It is proposed that the assessment of basal plasma renin activity together with florinef suppression of plasma aldosterone are the most effective and convenient outpatient screening procedures in the diagnosis of primary aldosteronism.