Social determinants of health, personalized medicine, and child maltreatment.
Social determinants of health, personalized medicine, and child maltreatment.
复制标题
健康的社会决定因素、个性化医疗和虐待儿童。
DOI：
10.1038/s41390-020-01290-9
复制
发表时间：
2021
影响因子：
3.6
通讯作者：
Dubowitz,Howard
中科院分区：
文献类型：
--
作者：
Lane,WendyG;Dubowitz,Howard
本审查首先简要概述了虐待儿童作为一个主要公共卫生问题的重要性，因为它的普遍性和所涉及的巨大的人力和经济成本。然后，重点转向考虑个性化医疗和虐待儿童问题，包括遗传和基因组学因素，以及健康的社会决定因素的作用。介绍了与虐待和忽视儿童有关的表观遗传学研究，随后介绍了与贫困、父母抑郁和药物使用以及家庭（或亲密伴侣）暴力等一些具体社会因素有关的研究。审查结束时讨论了干预措施，以帮助解决健康的社会决定因素，并简要介绍了几个示范方案，在可预见的未来，个性化医疗在解决儿童虐待问题中的作用。影响本文综合了健康的社会决定因素以及与预防儿童虐待有关的遗传学和基因组学方面的进展。它提供了解决儿童虐待问题的模式方法的例子。在初级保健实践中防止虐待儿童。
This review begins with a brief summary of the importance of child maltreatment as a major public health problem, given its prevalence and the substantial human and economic costs involved. The focus then shifts to consideration of personalized medicine and child maltreatment, including genetic and genomics factors, as well as the role of social determinants of health. Research on epigenetics related to child abuse and neglect is presented, followed by that pertaining to a few specific social factors, such as poverty, parental depression and substance use, and domestic (or intimate partner) violence. The review ends with a discussion of interventions to help address social determinants of health with brief descriptions of several model programs, and thoughts concerning the role of personalized medicine in addressing child maltreatment in the foreseeable future.ImpactThis paper synthesizes knowledge on social determinants of health and advances in genetics and genomics related to the prevention of child maltreatment.It provides examples of model approaches to addressing the prevention of child maltreatment in primary care practices.