Accelerated whole-heart 3D CSPAMM for myocardial motion quantification
Accelerated whole-heart 3D CSPAMM for myocardial motion quantification
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DOI：
10.1002/mrm.21363
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发表时间：
2008-04-01
影响因子：
3.3
通讯作者：
Kozerke, Sebastian
中科院分区：
文献类型：
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作者：
Rutz, Andrea K.;Ryf, Salome;Kozerke, Sebastian
使用磁化的互补空间调制（CSPAMM）的心肌组织标记允许详细评估心肌运动。为了捕获复杂的3D心脏运动模式，通常在不同的方向上采集多个2D标记切片。这些方法容易出现切片配准不良，并且与长采集时间相关联。在这项工作中，提出了一种用于获取3D CSPAMM数据的快速方法，该方法允许测量整个心脏在三次屏气中的变形，每次屏气18次心跳。在每个正交方向上依次执行三次采集，并准备线标签。通过应用局部标记准备和混合多激发、分段回波平面成像序列来实现测量加速。测量了5名健康志愿者和5名心肌梗死患者。在整个心动周期中使用谐波相位（HARP）技术的增强变体跟踪中壁轮廓。在健康受试者中，收缩末期的周长缩短范围为14.1%（基线）至20.1%（心尖）。患者的运动功能减退区域与注射造影剂后表现出高增强的区域对应良好。患者左心室至最大环周缩短时间的差异比志愿者更显著（P < 0.01）。建议的测量方案是患者耐受良好，并具有相当大的潜力，调查心脏力学在各种疾病。
Myocardial tissue tagging using complementary spatial modulation of magnetization (CSPAMM) allows detailed assessment of myocardial motion. To capture the complex 3D cardiac motion pattern, multiple 2D tagged slices are usually acquired in different orientations. These approaches are prone to slice misregistration and associated with long acquisition times. In this work, a fast method for acquiring 3D CSPAMM data is proposed that allows measuring deformation of the whole heart in three breath-holds of 18 heartbeats duration each. Three acquisitions are sequentially performed with line tag preparation in each orthogonal direction. Measurement acceleration is achieved by applying localized tagging preparation and a hybrid multishot, segmented echo-planar imaging sequence. Five healthy volunteers and five patients with myocardial infarction were measured. Midwall contours were tracked throughout the cardiac cycle with an enhanced variant of the harmonic phase (HARP) technique. Circumferential shortening at end-systole ranged from 14.1 % (base) to 20.1% (apex) in healthy subjects. Hypokinetic regions in patients corresponded well with regions exhibiting hyperenhancement after contrast injection. Time to maximum circumferential shortening varied more significantly over the left ventricle in patients than in volunteers (P < 0.01). The proposed measurement scheme was well tolerated by patients and holds considerable potential to investigate cardiac mechanics in various diseases.