Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota
Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota
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DOI：
10.1128/jcm.42.3.1203-1206.2004
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发表时间：
2004-03-01
影响因子：
9.4
通讯作者：
Schmidt, TM
中科院分区：
文献类型：
--
作者：
Young, VB;Schmidt, TM
肠道微生物群多样性的改变被认为是抗生素相关性腹泻（AAD）发生的基础。进行了分子系统发育分析，以记录 AAD 患者粪便细菌多样性的时间变化。抗生素的使用与肠道微生物群多样性的明显变化有关，包括产生丁酸盐的细菌的流行率显着下降。停用抗生素后，腹泻的缓解伴随着这些变化的逆转，这提供了第一个将胃肠道细菌群落结构的变化与 AAD 的发展联系起来的直接证据。
Alterations in the diversity of the gut microbiota are believed to underlie the development of antibiotic-associated diarrhea (AAD). A molecular phylogenetic analysis was performed to document temporal changes in the diversity of fecal bacteria of a patient who developed AAD. Antibiotic administration was associated with distinct changes in the diversity of the gut microbiota, including a marked decrease in the prevalence of butyrate-producing bacteria. Following the discontinuation of the antibiotic, resolution of diarrhea was accompanied by a reversal of these changes, providing the first direct evidence linking changes in the community structure of the gastrointestinal bacteria with the development of AAD.