Hormonal coordination of motor output and internal prediction of sensory consequences in an electric fish
Hormonal coordination of motor output and internal prediction of sensory consequences in an electric fish
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电鱼运动输出的激素协调和感觉后果的内部预测
DOI：
10.1016/j.cub.2023.06.069
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发表时间：
2023
期刊：
影响因子：
9.2
通讯作者：
Carlson, Bruce A.
中科院分区：
文献类型：
--
作者：
Fukutomi, Matasaburo;Carlson, Bruce A.
类固醇激素重塑神经网络以诱导行为的季节性或发育变化。行为中的荷尔蒙变化可能需要感觉运动整合的协调变化。在这里，我们研究了激素对预测运动信号（称为推论放电）的影响，该信号调节弱电斑鸠鱼的感觉处理。在介导交流行为的电感觉通路中，由必然放电激活的抑制作用会阻止对自生电脉冲的感觉反应，从而使下游电路能够选择性地分析来自附近鱼类的通信信号。在繁殖季节，雄性睾丸激素水平的增加会延长这些脉冲。我们使用睾酮治疗诱导电脉冲伸长，发现随着电脉冲持续时间的增加，电感受器对自身产生的脉冲的反应时间被延迟。电感觉核和电动神经元的同步记录表明，睾酮会延迟和延长推论放电抑制的时间。此外，推论放电抑制时间的变化与受体对自生脉冲反应时间的变化精确匹配。然后我们询问抑制时间的变化是由睾酮对必然放电回路的直接作用引起的，还是由响应改变的感觉反馈而作用于回路的可塑性引起的。我们通过手术使鱼的电器官沉默，并发现完整鱼和沉默鱼之间的必然放电时间有类似的激素调节，这表明这种转变不需要感觉反馈。我们的研究结果表明，睾酮以协调的方式直接调节运动输出和对由此产生的感觉后果的内部预测。
Steroid hormones remodel neural networks to induce seasonal or developmental changes in behavior. Hormonal changes in behavior likely require coordinated changes in sensorimotor integration. Here, we investigate hormonal effects on a predictive motor signal, termed corollary discharge, that modulates sensory processing in weakly electric mormyrid fish. In the electrosensory pathway mediating communication behavior, inhibition activated by a corollary discharge blocks sensory responses to self-generated electric pulses, allowing the downstream circuit to selectively analyze communication signals from nearby fish. These pulses are elongated by increasing testosterone levels in males during the breeding season. We induced electric-pulse elongation using testosterone treatment and found that the timing of electroreceptor responses to self-generated pulses was delayed as electric-pulse duration increased. Simultaneous recordings from an electrosensory nucleus and electromotor neurons revealed that the timing of corollary discharge inhibition was delayed and elongated by testosterone. Furthermore, this shift in the timing of corollary discharge inhibition was precisely matched to the shift in timing of receptor responses to self-generated pulses. We then asked whether the shift in inhibition timing was caused by direct action of testosterone on the corollary discharge circuit or by plasticity acting on the circuit in response to altered sensory feedback. We surgically silenced the electric organ of fish and found similar hormonal modulation of corollary discharge timing between intact and silent fish, suggesting that sensory feedback was not required for this shift. Our findings demonstrate that testosterone directly regulates motor output and internal prediction of the resulting sensory consequences in a coordinated manner.
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DOI：
10.1007/bf00611588
发表时间：
1984-01-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY
影响因子：
--
作者：
BASS, AH;HOPKINS, CD
通讯作者：
HOPKINS, CD
电鱼 Gnathonemus petersii（mormyridae）侧线叶核的细胞学和免疫细胞化学：表明 GABA 能突触介导抑制性伴随放电的证据
影响因子：
2.3
作者：
E. Mugnaini;L. Maler
通讯作者：
L. Maler
电接收
DOI：
10.1201/9780429061608-17
发表时间：
2020
期刊：
Fish Larval Physiology
影响因子：
--
作者：
F. Kirschbaum;J. Denizot
通讯作者：
J. Denizot
信号多样化与弱电鱼的必然放电演化有关
DOI：
10.1523/jneurosci.0875-20.2020
发表时间：
2020
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
Fukutomi, Matasaburo;Carlson, Bruce A.
通讯作者：
Carlson, Bruce A.
西非斑尾电鱼群落电信号的多样性
影响因子：
2.6
作者：
C. Hopkins
通讯作者：
C. Hopkins