Expression of tumour markers CA50, CEA and TPA in female breast carcinoma as related to histopathological findings and survival.
Expression of tumour markers CA50, CEA and TPA in female breast carcinoma as related to histopathological findings and survival.
复制标题
女性乳腺癌中肿瘤标志物 CA50、CEA 和 TPA 的表达与组织病理学结果和生存相关。
作者：
M. Eskelinen;P. Lipponen;K. Syrjänen
通过免疫组织化学法（使用染色指数 I）测定 114 例女性乳腺癌石蜡包埋活检标本中肿瘤标志物 CEA、TPA 和 CA 50 的表达，特别强调肿瘤组织学和患者预后。患者的平均 (SD) 年龄为 58.1 (13.1) 岁，前瞻性随访平均为 12.4 年。平均（SD）染色指数（I）值如下：对于CEA 0.14（0.35）（范围0.00-3.00），对于TPA 2.01（0.77）（范围0.00-3.00），对于CA 50 0.36（0.67）（范围0.00-3.00）。 I 级肿瘤的 TPA 阳性率高于 III 级肿瘤 (p = 0.0038)。细胞核的不规则性与 TPA 阳性相关，具有规则细胞核的肿瘤比具有高度不规则细胞核的肿瘤具有更高的 TPA 阳性 I 值 (p = 0.08)。乳腺癌相关生存率也与 TPA 阳性显着相关 (p = 0.047)。 CEA 和 CA 50 阳性与临床或组织学变量没有显着相关。通过 CEA 或 CA 50 定量无法显着预测存活率。我们的结果表明，可以定量石蜡切片中乳腺癌中肿瘤标志物 CEA、TPA 和 CA 50 的表达。 CEA 和 CA 50 免疫组织化学对乳腺癌不具有任何显着的预测价值，而 TPA 表达可用于区分乳腺癌的恶性亚型和良性亚型。
Expression of the tumour markers CEA, TPA and CA 50 was determined immunohistochemically (using a staining index, I) in paraffin embedded biopsy specimens from 114 female breast carcinomas, with special emphasis on tumour histology and patient prognosis. The mean (SD) age of the patients was 58.1 (13.1) years and they were prospectively followed-up for a mean of 12.4 years. The mean (SD) staining index (I) values were as follows: for CEA 0.14 (0.35) (range 0.00-3.00) for TPA 2.01 (0.77) (range 0.00-3.00) and for CA 50 0.36 (0.67) (range 0.00-3.00). Grade I tumours showed higher positivity for TPA than grade III tumours (p = 0.0038). The irregularity of nuclei was related to TPA positivity, in that the tumours with regular nuclei had higher I values for TPA positivity, than tumours with highly irregular nuclei (p = 0.08). Breast cancer-related survival significantly correlated with TPA positivity as well (p = 0.047). The CEA and CA 50 positivity were not significantly related to clinical or histological variables. Survival could not be predicted significantly by means of CEA or CA 50 quantitation. Our results show that it is possible to quantitate the expression of the tumour markers CEA, TPA and CA 50 in breast cancer in paraffin sections. CEA and CA 50 immunohistochemistry does not possess any significant predictive value in breast cancer, whereas TPA expression might be utilized in discriminating malignant subtypes of breast cancers from the more benign ones.