Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction.
Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction.
复制标题
组蛋白脱乙酰酶 HDAC5 向细胞核的调节穿梭可能会抑制可卡因成瘾。
DOI：
10.1016/j.neuron.2011.12.016
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发表时间：
2012
期刊：
影响因子：
16.2
通讯作者：
West,AnneE
中科院分区：
文献类型：
--
作者：
West,AnneE
组蛋白去乙酰化酶HDAC5已被证明可以调节对可卡因的行为适应。在本期《神经元》中，谷口等人。（2012）描述了调节HDAC 5的核积累的cAMP依赖性信号传导途径，表明了将可卡因与HDAC 5功能变化偶联的机制。
The histone deacetylase HDAC5 has been shown to regulate behavioral adaptations to cocaine. In this issue ofNeuron, Taniguchi et al. (2012) describe a cAMP-dependent signaling pathway that regulates nuclear accumulation of HDAC5, suggesting a mechanism to couple cocaine with changes in HDAC5 function.